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DOI: 10.47026/2413-4864-2026-3-710-86
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Vikhareva L.V., Novikov E.I., Goryunov A.A., Boyko A.E., Petrov D.I.

Cellular and molecular aspects of kidney regeneration as factors determining the outcome of ischemic reperfusion injury

Keywords: kidney, ischemia-reperfusion, regeneration, acute kidney injury, signaling pathways, anastasis, programmed cell regeneration

The processes of ischemia and subsequent reperfusion underlie a significant part of cases of acute kidney injury, they are also the predominant risk factor for adverse outcomes during organ transplantation. Insufficient understanding of molecular foundations and determinants of this process significantly slows down the emergence of new strategies aimed at preserving kidney function. This review is devoted to the analysis of cellular and molecular processes that determine the regenerative response of renal tissue after ischemia-reperfusion, as well as factors affecting the balance between restoration of the nephron structure and the development of pathological remodeling and chronic organ dysfunction. The paper examines the key stages of kidney damage in hypoxia and subsequent reoxygenation, including energy deficiency, mitochondrial dysfunction, oxidative stress, inflammatory response and activation of various forms of programmed cell death. Special attention is paid to the early post-reperfusion stage as a critical period of switching from damage to regeneration, in which innate and adaptive immune cells, polarization of macrophages, endothelial dysfunction and restoration of microcirculation play the central role. The key part of the review summarizes modern views of cellular sources of renal tubule regeneration and molecular mechanisms underlying this process. The involvement of the Wnt/β-catenin, Notch and Hippo–YAP/TAZ signaling pathways in regulation of cell plasticity, proliferation and differentiation is analyzed. A separate section is devoted to promising concepts of cell death reversibility, such as anastasis and programmed cell regeneration, which potentially expand the regenerative pool of cells. It is emphasized that spatiotemporal coordination of these processes is a key factor determining the outcome of ischemic reperfusion injury to the kidney.

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About authors

Vikhareva Larisa V.
Doctor of Medical Sciences, Professor, Department of Human Anatomy, Topographic Anatomy and Operative Surgery, Director, Institute of Fundamental Medicine, Tyumen State Medical University, Russia, Tyumen (vikharevalv@yandex.ru; ORCID: https://orcid.org/0000-0001-6864-4417)
Novikov Evgeniy I.
Head of the Youth Research Laboratory "MorphoLab", Institute of Fundamental Medicine, Tyumen State Medical University, Russia, Tyumen (enovikov307@gmail.com; ORCID: https://orcid.org/0000-0002-5931-3648)
Goryunov Anton A.
Post-Graduate Student, Cell Biology Program, Laboratory Assistant, Youth Research Laboratory "MorphoLab", Institute of Fundamental Medicine, Tyumen State Medical University, Russia, Tyumen (Simsom2@mail.ru; ORCID: https://orcid.org/0009-0008-4564-1625)
Boyko Angelina E.
District Physician, City Polyclinic No. 3, Russia, Tyumen (angeblina@mail.ru; ORCID: https://orcid.org/0009-0007-2919-0521)
Petrov Daniil I.
Assistant Lecturer, Department of Dermatovenereology and Cosmetology, Tyumen State Medical University, Russia, Tyumen (tgmu@tyumsmu.ru; ORCID: https://orcid.org/0000-0003-2705-1927)

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Vikhareva L.V., Novikov E.I., Goryunov A.A., Boyko A.E., Petrov D.I. Cellular and molecular aspects of kidney regeneration as factors determining the outcome of ischemic reperfusion injury [Electronic resource] // Acta medica Eurasica. – 2026. – №3. P. 710-86. – URL: https://acta-medica-eurasica.ru/en/single/2026/3/9/. DOI: 10.47026/2413-4864-2026-3-710-86.

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