Morphometric study of neurons, glia and lipofuscin in the mastoid bodies in men and women aged 22–35 years

DOI: 10.47026/2413-4864-2026-3-31-36

UDC: 611.81-018.82:611.813.1-053.8
BBC: Е903.23

Pavlov A.V., Timofeev V.E., Suchkov D.I., Zherebyateva S.R., Pemurov K.K.

Morphometric study of neurons, glia and lipofuscin in the mastoid bodies in men and women aged 22–35 years

Keywords: mastoid bodies, corpora mamillaria, sexual dimorphism, lipofuscin, glial index, morphometry

Mastoid bodies are an important part of the limbic system. Data on their cytoarchitectonics in individuals of different sexes at a young age remains incomplete. The aim of the study was to compare the quantitative parameters of neurons, glial cells and microvessels in the medial nuclei of the mastoid bodies in men and women aged 22–35 years. Materials and methods. The autopsy material of 150 people (73 men, 77 women) aged 22–35 years was studied. Sections of the mastoid bodies were stained with hematoxylin-eosin and thionine by Nissl method. Morphometric analysis included quantification of neurons, glial cells, microvessels, assessment of cell area and accumulation of lipofuscin. Statistical processing was applying Mann–Whitney U-test. Results. Men have fewer neurons (86.91±5.00 versus 99±8.00 in women, p < 0.001) and more glial cells (427.57±13.00 versus 319±19.00, p < 0.001). The glial index in men was 4.92±0.32, in women it was 3.22±0.32 (p < 0.001). Lipofuscin granules in neuronal cytoplasm were found mainly in men (4.60±1.00 cells per 5 visual fields, 5.7% of the number of neurons). The number of microvessels, the degree of vascularization, the area of neurons and their nuclei had no statistically significant differences by gender. Conclusions. During the period of 22–35 years in men, compared with women, the number of neurons in the medial nuclei of the mastoid bodies is decreased (by 12.2%), the number of glial cells is increased (by 34.0%), the glial index is increased (by 52.8%) and lipofuscin accumulates. This indicates an earlier onset of metabolic changes in men.

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About authors

Pavlov Artem V.: Doctor of Medical Sciences, Professor, Head of the Anatomy Department, Ryazan State Medical University, Russia, Ryazan (av.pavlov-rzgmu@yandex.ru; ORCID: https://orcid.org/0000-0002-8224-824X)

Timofeev Vasily E.: Candidate of Medical Sciences, Associate Professor, Department of Anatomy, Ryazan State Medical University, Russia, Ryazan (laminacribroza62@yandex.ru; ORCID: https://orcid.org/0000-0002-6329-6414)

Suchkov Dmitry I.: Candidate of Medical Sciences, Associate Professor, Department of Cardiovascular, X-ray Endovascular Surgery and Radiation, Ryazan State Medical University, Russia, Ryazan (argoncs@mail.ru; ORCID: https://orcid.org/0000-0001-5513-9104)

Zherebyateva Svetlana R.: Candidate of Medical Sciences, Associate Professor, Department of Anatomy, Ryazan State Medical University, Russia, Ryazan (pferdin@mail.ru; ORCID: https://orcid.org/0000-0001-8232-2748)

Pemurov Kirill K.: 4th year Student, Faculty of General Medicine, Ryazan State Medical University, Russia, Ryazan (kirillpemurov303@gmail.com; ORCID: https://orcid.org/0009-0003-4508-7584)

Article link

Pavlov A.V., Timofeev V.E., Suchkov D.I., Zherebyateva S.R., Pemurov K.K. Morphometric study of neurons, glia and lipofuscin in the mastoid bodies in men and women aged 22–35 years [Electronic resource] // Acta medica Eurasica. – 2026. – №3. P. 31-36. – URL: https://acta-medica-eurasica.ru/en/single/2026/3/4/. DOI: 10.47026/2413-4864-2026-3-31-36.

Single article

Pavlov A.V., Timofeev V.E., Suchkov D.I., Zherebyateva S.R., Pemurov K.K.