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Nikitina L.I., Dzhuraeva Sh.F., Vorobev M.V.
Modern approaches to the treatment of dental caries using bioactive materials and regenerative technologies
Keywords: dentine caries, bioactive materials, regenerative technologies, minimally invasive dentistry
Dentine caries remains the most common dental disease requiring the use of effective treatment methods aimed at preserving the viability of the pulp-dentine complex. Traditional approaches are giving way to the concept of minimally invasive intervention using bioactive materials. The purpose of the work is to analyze and systematize modern literature data on methods of treating dental caries using bioactive materials (domestic and international developments) and regenerative technologies. A literature search was performed in Russian (eLibrary, CyberLeninka) and international (PubMed, Scopus, Web of Science) bibliographic databases. The scope of the research covered the period 2015–2025, including several earlier works relevant to the topic. Combinations of keywords were used for the search: "dentine caries", "minimally invasive caries treatment", "reparative dentinogenesis", "vital pulpitis therapy", "regenerative dentistry". Inclusion criteria were original research, systematic reviews, meta-analyses. The analysis showed that modern principles of dentine caries treatment are based on the principles of minimally invasive intervention. Data on Russian glass ionomer cements produced by VladMiVa JSC ("Cemion", "Cemilite", "Aquion", "Argetsem", "Cemion A.R.T.") are presented, which, according to the results of independent studies, demonstrate high physico-mechanical properties and a caries-static effect. The regenerative potential of platelet-enriched fibrin was analyzed. The data on the clinical efficacy of bioactive silicate cements (MTA, Biodentine), which not only provide sealing, but also stimulate reparative dentinogenesis, are systematized. The most promising areas of dentine caries treatment are the use of bioactive materials (domestic and foreign ones) and the use of combined approaches with growth factors. Further randomized trials are needed to optimize clinical protocols.
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About authors
- Nikitina Louise I.
- Candidate of Medical Sciences, Associate Professor, Head of the Department of Propeadeutics of Dental Diseases and New Technologies, Chuvash State University, Russia, Cheboksary (prop.stom.zab@mail.ru; ORCID: https://orcid.org/0000-0003-4893-0314)
- Dzhuraeva Sharora F.
- Doctor of Medical Sciences, Professor, Department of Propaedeutics of Dental Diseases and New Technologies, Chuvash State University, Russia, Cheboksary (dsharora@mail.ru; ORCID: https://orcid.org/0000-0002-0149-5653)
- Vorobev Mikhail V.
- Doctor of Medical Sciences, Associate Professor, Head of the Department of Dentistry No. 2, Ivanovo State Medical University, Russia, Ivanovo (ivanovovita@mail.ru; ORCID: https://orcid.org/0000-0001-9174-9436)
Article link
Nikitina L.I., Dzhuraeva Sh.F., Vorobev M.V. Modern approaches to the treatment of dental caries using bioactive materials and regenerative technologies [Electronic resource] // Acta medica Eurasica. – 2026. – №2. P. 85-97. – URL: https://acta-medica-eurasica.ru/en/single/2026/2/8/. DOI: 10.47026/2413-4864-2026-2-85-97.