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Lyubimova L.V., Pavlova S.I., Pchelova N.N., Lyubimov E.A.
The Use of a Polyvalent Klebsiella Bacteriophage in Infection after Reconstructive Plastic Surgery on the Spine in a Child (a clinical case)
Keywords: spinal infection, polyresistant Klebsiella pneumoniae, polyvalent Klebsiella bacteriophage, biofilms, spondylodesis
The incidence of infection after reconstructive plastic surgery on the spine (in particular, spondylodesis) in children remains at a fairly high level and ranges from 0.4% to 8.7%. These complications are often caused by polyresistant bacterial pathogens; this accentuates the need for new effective therapeutic approaches. Bacteriophage preparations in combination with antibiotics can optimize existing strategies for the treatment of infectious diseases, since they are able to selectively destroy bacteria, including biofilm-forming ones. The aim of the study was to draw the attention of practitioners to modern problems of treating polyresistant infections on the example of a case of purulent complication after spinal surgery in a child. Materials and methods. On the basis of the FSBI "Federal Center for Traumatology, Orthopedics and Endoprosthetics" under the Health Ministry of the Russian Federation (the town of Cheboksary) a retrospective analysis of a clinical case of treating early infection after reconstructive plastic surgery on the spine caused by a polyresistant strain of Klebsiella pneumoniae was conducted. Research results. Patient P., 2.2 years old, with congenital pathology of the musculoskeletal system, who repeatedly received medical care in various medical organizations, underwent surgical spine stabilization. In the early postoperative period, an infectious complication developed caused by a polyresistant strain of Klebsiella pneumoniae (a producer of extended-spectrum beta-lactamases and carbapenemases). Along with surgical debridement of the postoperative wound, a combined etiotropic antibacterial therapy was performed (12 weeks). However, complete healing of the postoperative wound was achieved in combination with the administration of a polyvalent klebsiella bacteriophage (10 weeks). Conclusions. This clinical case demonstrates that the use of a polyvalent klebsiella bacteriophage can increase the effectiveness of antibacterial pharmacotherapy in surgical treatment with preservation of metal structures.
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About authors
- Lyubimova Lyudmila V.
- Clinical Pharmacologist, Federal Center for Traumatology, Orthopedics and Arthroplasty, Russia, Cheboksary (borisova-80@mail.ru; ORCID: https://orcid.org/0000-0002-5750-4459)
- Pavlova Svetlana I.
- Doctor of Medical Sciences, Head of the Department of Pharmacology, Clinical Pharmacology and Biochemistry, Chuvash State University, Russia, Cheboksary (flavonoid@yandex.ru; ORCID: https://orcid.org/0000-0001-9976-7866)
- Pchelova Nadezhda N.
- Doctor of Clinical Laboratory Diagnostics, Federal Center for Traumatology, Orthopedics and Arthroplasty, Russia, Cheboksary (nadyapchelova@mail.ru; ORCID: https://orcid.org/0000-0001-9507-9118)
- Lyubimov Evgeniy A.
- Anesthesiologist-Resuscitator, Federal Center for Traumatology, Orthopedics and Arthroplasty, Russia, Cheboksary (fc@orthoscheb.com; ORCID: https://orcid.org/0000-0001-5262-0197)
Article link
Lyubimova L.V., Pavlova S.I., Pchelova N.N., Lyubimov E.A. The Use of a Polyvalent Klebsiella Bacteriophage in Infection after Reconstructive Plastic Surgery on the Spine in a Child (a clinical case) [Electronic resource] // Acta medica Eurasica. – 2024. – №1. P. 66-73. – URL: https://acta-medica-eurasica.ru/en/single/2024/1/7/. DOI: 10.47026/2413-4864-2024-1-66-73.