Single article

DOI: 10.47026/2413-4864-2022-3-1-11

Diomidova V.N., Zakharova O.V., Safonova M.A., Valeeva O.V.

Analysis of the Correlational Relationship Between the Results of Ultrasound Elastography and the Values of the Measured Diffusion Coefficient in Assessing Uterine and Adnexal Structures in Reproductive Age Women

Keywords: elastography, shear wave, elastometry, measured diffusion coefficient, uterus, ovaries, magnetic resonance imaging, correlation

The purpose of the study. To study the correlational relationship between the results obtained by examining the uterus and ovaries in healthy women of reproductive age using shear wave ultrasound elastography with elastometry and magnetic resonance imaging (MRI) and assessment of the measured diffusion coefficient (MDC) of diffusion-weighted images (DWI). Materials and methods. The study group consisted of 45 healthy women of reproductive age (the average age was 32.9±3.1 years). All of them underwent ultrasound examination with the technology of two-dimensional shear wave elastography with elastometry (Aixplorer, Supersonic Imagine, France) according to the method developed and implemented by us. The MRI of uterine and ovarian structures was performed using the DWI protocol (Excelart Vantage Atlas magnetic resonance tomograph, Toshiba, Japan, 1.5 T), the myometrium and the uterine mucosa in the body and cervix, ovaries were evaluated. In the automatic mode, the MDC of unaltered structures in the uterine body and cervix and their appendages was calculated in the area of interest on ADC-maps. The degree of correlational relationship between the results of ultrasound elastography with elastometry and magnetic resonance tomography with an estimate of the measured diffusion coefficient was calculated. Results. Correlation analysis of the relationship between rigidity and the MDC of uterine and adnexal structures showed a direct inverse relationship between these values and a high degree of connection by Cheddock scale (p = 0.000000). At this, lesser MDC values (mm2 /s) of similar structures of the organs under study corresponded to large quantitative values of the Young's elasticity modulus (kPa) of all uterine and ovarian structures. Conclusion. The obtained data make it possible to optimize the diagnostic algorithm and to supplement the standard protocols for ultrasound and magnetic resonance imaging studies of gynecological organs using two-dimensional shear wave elastography with elastometry and magnetic resonance tomography with an assessment of the measured diffusion coefficient of diffusion-weighted images.

References

  1. Adamyan L.V., Panov V.O., Makiyan Z.N., Kulabukhova E.A., Panova M.M., Stashuk G.A., Stepanyan A.A. Magnitno-rezonansnaya tomografiya v differentsial’noi diagnostike anomalii matki i vlagalishcha: algoritm issledovaniya i MRT semiotika[Magnetic-Resonance Imaging in the Differential Diagnosis Anomalies of the Uterus and Vagina: Algorithm Research and MRI Semiotics]. Meditsinskaya vizualizatsiya, 2009, vol. 6, pp. 100–113.
  2. Gelezhe P.B., Trofimenko I.A., Morozov S.P. Osnovy interpretatsii diffuzionno-vzveshennoi tomografii vsego tela[The Basics of Whole Body Diffusion-Weighted Imaging Interpretation]. REJR, 2015, vol. 5(3), pp. 65–73.
  3. Diomidova V.N., Safonova M.A., Zakharova O.V., Dmitrieva A.N., Efimova O.A. Informativnost’ magnitno-rezonansnoi tomografii s primeneniem protokola diffuzionno-vzveshennykh izobrazhenii v otsenke endometriya pri polineoplaziyakh[The Informative Value of Magnetic Resonance Imaging with the Application of the Protocol of Diffusion-Weighted Images in the Assessment of the Endometrium when Multiple Neoplasias]. Issledovaniya i praktika v meditsine, 2020, vol. 7(4), pp. 51–61. DOI: https://doi.org/10.17709/2409-2231-2020-7-4-5.
  4. Diomidova V.N., Zakharova O.V., Petrova O.V., Siordiya A.A. Ul’trazvukovaya elastografiya (kompressionnaya i sdvigovoi volnoi) v akusherstve i ginekologii[Ultrasound (Compression and Shear Wave) Elastography in Obstetrics and Gynaecology]. Voprosy ginekologii, akusherstva i perinatologii, 2016, vol. 15(2), pp. 52–58.
  5. Diomidova V.N., Zakharova O.V., Petrova O.V. Elastografiya sdvigovoi volnoi v otsenke endometriya i miometriya u zdorovykh zhenshchin reproduktivnogo vozrasta [Endometrium and Myometrium Shear Wave Elastography in Healthy Women of Repzoductive Age]. Ul’trazvukovaya i funktsional’naya diagnostika, 2015, vol. 5, pp. 51–56.
  6. Diomidova V.N., Zakharova O.V., Siordiya A.A. Prognosticheskoe znachenie kolichestvennogo pokazatelya modulya uprugosti Yunga endometriya pri vtorichnom besplodii [Prognostic Significance of the Quantitative Measurement of Young’s Modulus of the Endometrium in Secondary Infertility]. Voprosy ginekologii, akusherstva i perinatologii, 2020, vol. 19(2), pp. 22–26. DOI: 10.20953/1726-1678-2020-2-22-26.
  7. Izranov V.A., Kazantseva N.V., Martinovich M.V., But-Gusaim V.I., Stepanyan I.A. Fizicheskie osnovy elastografii pecheni[Physical Foundations of Liver Elastography]. Vestnik Baltiiskogo federal’nogo universiteta im. I. Kanta. Ser. Estestvennye i meditsinskie nauki, 2019, vol. 2, pp. 69–87.
  8. Il’yasov K.A. Kolichestvennoe izmerenie diffuzii in vivo metodom magnitno-rezonansnoi tomografii[Quantitative measurement of diffusion in vivo by magnetic resonance imaging]. Uchenye zapiski Kazanskogo universiteta. Ser. Fiziko-matematicheskie nauki, 2011, vol. 153(1), pp. 17–37.
  9. Kainova E.P., Kaliparova M.P., Meteleva T.A., Olina A.A. Primenenie magnitno-rezonansnoi tomografii v ginekologicheskoi praktike[The use of magnetic resonance imaging in gynecological practice]. In: Sbornik nauchnykh trudov po itogam mezhdunarodnoi nauchno-prakticheskoi konferentsii «Novshestva v meditsine i farmakologii» (Tyumen’, 25 dekabrya) [Proc. of Int. Sci. Conf. «Innovations in medicine and pharmacology» (Tyumen, December 25)]. Tyumen, 2016, pp. 7–9.
  10. Karel’skaya N.A., Karmazanovskii G.G. Diffuzionno-vzveshennaya magnitno-rezonansnaya tomografiya vsego tela [Diffusion-weighted magnetic resonance imaging of the whole body].  Zhurnal im. N.I. Pirogova, 2010, vol. 8, pp. 57–60.
  11. Morozov S.P., Shelekhov P.V., Vladzimirskii A.V. Sovremennye standartizovannye podkhody k sovershenstvovaniyu sluzhby luchevoi diagnostiki[Modern Approaches to the Radiologyservice Improvement]. Problemy standartizatsii v zdravookhranenii, 2019, vol. 5-6, pp. 30–34. DOI: 10.26347/1607-2502201905-06030-034.
  12. Rogozhin V.A. MRT v ginekologicheskoi praktike[MRI in gynecological practice]. Russian electronic journal of radiology, 2012, vol. 2(3), pp. 27–40.
  13. Rubtsova N.A., Novikova E.G., Sinitsyn V.E. Vozmozhnosti MRT v predoperatsionnoi otsenke mestnoi rasprostranennosti raka sheiki matki[MRI Opportunities in Cervical Cancer Local Staging Preoperative Evaluation]. Akusherstvo, ginekologiya i reproduktsiya, 2012, vol. 6(3), pp. 6–13.
  14. Sergienya O.V., Yukhno E.A., Pavlovskaya E.A., Fokin V.A., Trufanov G.E. Vozmozhnosti magnitno-rezonansnoi tomografii v vizualizatsii strukturnykh izmenenii organov malogo taza u zhenshchin reproduktivnogo vozrasta pri besplodii[Magnetic Resonance Imaging in Visualization of Structural Changes in the Pelvic Organs in Women of Reproductive Age with Infertility]. REJR, 2018, vol. 8(1), pp. 119–128. DOI: 10.21569/2222-7415-2018-8-1-119-128.
  15. Solopova A.E., Makatsariya A.D., Sdvizhkov A.M., Ternovoi S.K. Magnitno-rezonansnaya tomografiya v differentsial’noi diagnostike obrazovanii yaichnikov. Vozmozhnosti kolichestvennoi mul’tiparametricheskoi otsenki[Magnetic resonance imaging in the differential diagnosis of ovarian formations. Possibilities of quantitative multiparameter estimation]. Akusherstvo i ginekologiya, 2017, vol. 2, pp. 80–85.
  16. Stolyarova I.V., Yakovleva E.K., Sharakova V.V. Otsenka diagnosticheskoi effektivnosti metodiki diffuzionno-vzveshennykh MR-izobrazhenii v diagnostike patologii tela matki [Evaluation of Diagnostic Effectiveness of the Method of Diffusion-Weighted Mr-Images in Diagnosis of Pathology of the Uterine Body]. Voprosy onkologii, 2015, vol. 61(6), pp. 986–693.
  17. Stolyarova I.V, Yakovleva E.K, Sharakova V.V. Rezul’taty effektivnosti metodiki diffuzionno-vzveshennykh izobrazhenii (DVI) v diagnostike raka endometriya[The results of the effectiveness of the diffusion-weighted imaging (DWI) technique in the diagnosis of endometrial cancer]. Meditsinskii alfavit, 2016, vol. 1(25), pp. 47–53.
  18. Tarachkova E.V., Strel’tsova O.N., Bazaeva I.Ya., Akhverdieva G.I., Panov V.O., Kravets O.A., Tyurin I.E. Vozmozhnosti magnitno-rezonansnoi tomografii v diagnostike raka sheiki matki[Capabilities of magnetic resonance imaging in the diagnosis of cancer of the cervix uteri]. Opukholi zhenskoi reproduktivnoi sistemy, 2014, no. 3, pp. 78–85.
  19. Fedorov M.A., Diomidova V.N., Migushkina L.P. Rol’ magnitno-rezonansnoi tomografii v povyshenii kachestva okazaniya meditsinskoi pomoshchi bol’nym s ishemicheskim insul’tom [The Role of Magnetic Resonance Imaging in Improving the Quality of Medical Care in Patients with Ischemic Stroke]. Prakticheskaya meditsina, 2015, vol. 6(91), pp. 115–118.
  20. Khoruzhik S.A., Dulinets I.S. Sravnitel’naya normal’naya anatomiya sheiki matki na T1-, T2- i diffuzionno-vzveshennykh magnitno-rezonansnykh izobrazheniyakh[Comparative normal anatomy of the cervix on T1, T2, and diffusion-weighted magnetic resonance images]. Meditsinskaya vizualizatsiya, 2012, vol. 2, pp. 71–80.
  21. Diomidova V.N., Zakharova O.V., Siordiya A.A., Chameeva T.V., Vinogradova V.S. Ultrasonic elastography of shear wave with elastometry in defining normative values of young”s modulus of elasticity of the ovaries in women of reproductive age. Gynecology, Obstetrics and Perinatology, 2018, vol. 17(2), pp. 32–35.
  22. Frank M.L., Schäfer S.D., Möllers M., Falkenberg M.K., Braun J., Möllmann U. et al. Importance of Transvaginal Elastography in the Diagnosis of Uterine Fibroids and Adenomyosis. Ultraschall Med., 2015, Aug. 14. DOI: 10.1055/s-0035-1553266.
  23. Haider M.A., Amoozadeh Y., Jhaveri K., Dow-Mu K., Thoeny H.C. DW-MRI for Disease Characterization in the Pelvis. In: Dow-Mu K, Thoeny HC, editors. Diffusion-Weighted MR Imaging. Berlin, Heidelberg: Springer-Verlag, 2008, pp. 143–156.
  24. Low R.N., Sebrechts C.P., Barone R.M., Muller W. Diffusion-weighted MRI of peritoneal tumors: comparison with conventional MRI and surgical and histopathologic findings-a feasibility study.  American journal of roentgenology, 2009, vol. 08-193(2), pp. 461–470.
  25. Preis K., Zielinska K., Swiatkowska-Freund M., Wydra D., Kobierski J. The role of elastography in the differential diagnosis of endometrial pathologies–preliminary report. Ginekol Pol.,2011, vol. 82(7), pp. 494–497.
  26. Shiina T., Nightingale K.R., Palmeri M.L. et al. WFUMB guidelines and terminology. Ultrasound Med Biol., 2015, vol. 41, pp. 1126–1147.
  27. Wood C.D., Vijayvergia M., Miller F.H., Carroll T., Fasanati C., Shea L.D. et al. Multi-modal magnetic resonance elastography for noninvasive assessment of ovarian tissue rigidity in vivo. Acta Biomater., 2015, vol. 13, pp. 295–300. DOI: 10.1016/j.actbio.2014.11.022.

About authors

Diomidova Valentina N.
Doctor of Medical Sciences, Professor, Dean of the Medical Faculty, Head of Department of Propaedeutics of Internal Medicine with a Course of Radiation Diagnostics, Chuvash State University, Russia, Cheboksary (diomidovavn@rambler.ru; ORCID: https://orcid.org/0000-0002-3627-7971)
Zakharova Oksana V.
Candidate of Medical Sciences, Obstetrician-Gynaecologist at the Obstetric Department, University Clinical Hospital № 2, I.M. Sechenov First Moscow State Medical University, Russia, Moscow (zaharova260272@mail.ru; ORCID: https://orcid.org/https://orcid.org/0000-0003-3728-963X)
Safonova Marina A.
Candidate of Medical Sciences, Associate Professor, Department of Propaedeutics of Internal Diseases with a Course of Radiology, Chuvash State University; Head of X-ray Diagnostics Department, Republican Clinical Oncologic Dispensary, Russia, Cheboksary (safmaran@yandex.ru; ORCID: https://orcid.org/0000-0002-8578-6449)
Valeeva Olga V.
Candidate of Medical Sciences, Associate Professor, Department of Propaedeutics of Internal Diseases with a Course of Radiation Diagnostics, Chuvash State University, Russia, Cheboksary (valeeva-usd@mail.ru; ORCID: https://orcid.org/0000-0002-0349-1883)

Article link

Diomidova V.N., Zakharova O.V., Safonova M.A., Valeeva O.V. Analysis of the Correlational Relationship Between the Results of Ultrasound Elastography and the Values of the Measured Diffusion Coefficient in Assessing Uterine and Adnexal Structures in Reproductive Age Women [Electronic resource] // Acta medica Eurasica. – 2022. – №3. P. 1-11. – URL: https://acta-medica-eurasica.ru/en/single/2022/3/1/. DOI: 10.47026/2413-4864-2022-3-1-11.