The Effect of COVID-19 on Myocardial Damage: a Clinical Case

DOI: 10.47026/2413-4864-2022-2-31-39

UDC: 616.98:578.834.1+616.127-005.8
BBC: 54.1

Zhuravleva N.V., Babokin V.E., Barsukova E.V., Karzakova L.M., Fomina R.V., Komelyagina N.A., Smirnova T.L., Platonova K.I., Ukhterova N.D., Lutkova T.S., Markelova L.L.

The Effect of COVID-19 on Myocardial Damage: a Clinical Case

Keywords: new coronavirus infection COVID-19, cardiovascular diseases, SARS-CoV-2, myocardial damage

Despite the fact that the general clinical manifestations of COVID-19 are well known, there remain problems associated with the impact of COVID-19 on human health, in addition to its effects on the respiratory system. Patients with COVID-19 and concomitant cardiovascular diseases are more likely to be hospitalized and to pass treatment in the intensive care units and to have worse prognoses. The article discusses the problems arising from the effect of type 2 coronavirus acute respiratory syndrome (SARS-CoV-2) on the cardiovascular system, starting with the mechanisms associated with angiotensin converting enzyme 2 (ACE2) receptors, as well as discusses cases of major pathological changes in the heart and blood vessels that are detected in these patients. In addition to the known risk factors for severe COVID-19: cardiovascular diseases, diabetes mellitus, chronic lung diseases and old age, even young patients without a history of risk factors may develop myocardial damage. We present a description of a clinical case of acute myocardial infarction against the background of a new coronavirus infection COVID-19 in a patient aged 28 years with a diagnosis of coronary heart disease.

References

ARDS Definition Task Force, Ranieri V.M., Rubenfeld G.D., Thompson B.T., Ferguson N.D., Caldwell E. et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA, 2012, vol. 307, no. 23, pp. 2526–2533. DOI: 10.1001/jama.2012.5669.
Ge X.Y., Li J.L., Yang X.L., Chmura A.A., Zhu G. et al. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature, 2013, vol. 503, no. 7477, pp. 535–538. DOI: 10.1038/nature12711.
Govaert T.M., Thijs C.T., Masurel N., Sprenger M.J., Dinant G.J., Knottnerus J.A. The efficacy of influenza vaccination in elderly individuals. A randomized double-blind placebo-controlled trial. JAMA, 1994, vol. 272, no. 21, pp. 1661–1665.
Huang C., Wang Y., Li X., Ren L., Zhao J. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 2020, vol. 395, no. 10223, pp. 497–506. DOI: 10.1016/S0140-6736(20)30183-5.
Klok F.A., Kruip M.J.H.A., van der Meer N.J.M., Arbous M.S., Gommers D.A.M.P.J. et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res., 2020, vol. 191, pp. 145–147. DOI: 10.1016/j.thromres.2020.04.013.
Kwong J.C., Schwartz K.L., Campitelli M.A., Chung H., Crowcroft N.S. et al. Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection. N Engl J Med., 2018, vol. 378, no. 4, pp. 345–353. DOI: 10.1056/NEJMoa1702090.
Li L.Q, Huang T., Wang Y.Q., Wang Z.P., Liang Y. COVID-19 patients’ clinical characteristics, discharge rate, and fatality rate of meta-analysis. J Med Virol., 2020, Vol. 92, no. 6, pp. 577–583. DOI: 10.1002/jmv.25757.
Liu W.M., van der Zeijst B.A., Boog C.J., Soethout E.C. Aging and impaired immunity to influenza viruses: implications for vaccine development. Hum Vaccin., 2011, no. 7, pp. 94–98. DOI: 10.4161/hv.7.0.14568.
Murthy S., Gomersall C.D., Fowler R.A. Care for Critically Ill Patients With COVID-19. JAMA, 2020, vol. 323, no. 15, pp. 1499–1500. DOI: 10.1001/jama.2020.3633.
Ruan Q., Yang K., Wang W., Jiang L., Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med., 2020, vol. 46, no. 5, pp. 846– DOI: 10.1007/s00134-020-05991-x.
Tall AR, Yvan-Charvet L. Cholesterol, inflammation and innate immunity. Nat Rev Immunol., 2015, vol. 15, no. 2, pp. 104– DOI: 10.1038/nri3793.
Thygesen K., Alpert J.S., Jaffe A.S., Chaitman B.R., Bax J.J. et al; Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction. Fourth Universal Definition of Myocardial Infarction (2018). J Am Coll Cardiol., 2018, vol. 72, no. 18, pp. 2231–2264. DOI: 10.1016/j.jacc.2018.08.1038.
Wang D., Hu B., Hu C., Zhu F., Liu X. et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA, 2020, vol. 323, no. 11, pp. 1061– DOI: 10.1001/jama.2020.1585.
Wu Z., McGoogan J.M. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA, 2020, vol. 323, no. 13, pp. 1239– DOI: 10.1001/jama.2020.2648.
Zhang H., Penninger J.M., Li Y., Zhong N., Slutsky A.S. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Med., 2020, vol. 46, no. 4, pp. 586– DOI: 10.1007/s00134-020-05985-9.
Zheng Y.Y., Ma Y.T., Zhang J.Y., Xie X. COVID-19 and the cardiovascular system. Nat Rev Cardiol., 2020, vol. 17, no. 5, pp. 259– DOI: 10.1038/s41569-020-0360-5.
Zhou F., Yu T., Du R., Fan G., Liu Y. et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet., 2020, vol. 395, no. 10229, pp.1054– DOI: 10.1016/S0140-6736(20)30566-3.
Zhou P., Yang X.L., Wang X.G., Hu B., Zhang L. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 2020, vol. 579, no. 7798, pp. 270–273. DOI: 10.1038/s41586-020-2012-7.
Zidar D.A., Al-Kindi S.G., Liu Y., Krieger N.I., Perzynski A.T. et al. Association of Lymphopenia With Risk of Mortality Among Adults in the US General Population. JAMA Netw Open., 2019, vol. 2, no. 12: e1916526. DOI: 10.1001/jamanetworkopen.2019.16526.
Zompatori M., Ciccarese F., Fasano L. Overview of current lung imaging in acute respiratory distress syndrome. Eur Respir Rev., 2014, vol. 23, no. 134, pp. 519–5 DOI: 10.1183/09059180.00001314.

About authors

Zhuravleva Nadezhda V.: Candidate of Medical Sciences, Associate Professor, Department of Internal Medicine , Chuvash State University, Russia, Cheboksary (zhuravlevanv@mail.ru; ORCID: https://orcid.org/0000-0001-6470-7724)

Babokin Vadim E.: Chief Physician, Republican Cardiology Dispensary; Doctor of Medical Sciences, Associate Professor, Head of the Department of Surgical Diseases, Chuvash State University, Russia, Cheboksary (rkd@med.cap.ru; ORCID: https://orcid.org/0000-0002-2788-8762)

Barsukova Elena V.: Chief Physician, Republican Clinical Hospital; Department Faculty and Hospital Therapy, Chuvash State University, Russia, Cheboksary (rkb@med.cap.ru; ORCID: https://orcid.org/0000-0001-8441-9391)

Karzakova Luiza M.: Doctor of Medical Sciences, Professor, Head of Internal Diseases Department, Chuvash State University, Russia, Cheboksary (luizak58@mail.ru; ORCID: https://orcid.org/0000-0002-5899-6352)

Fomina Rosa V.: Assistant Lecturer, Department of Instrumental Diagnostics with a Course of Phthisiology, Chuvash State University, Russia, Cheboksary (roza.fomina2012@yandex.ru; ORCID: https://orcid.org/0000-0002-4688-8901)

Komelyagina Nadezhda A.: Candidate of Medical Sciences, Associate Professor, Department of Internal Diseases, Chuvash State University, Russia, Cheboksary (comelya76@mail.ru; ORCID: https://orcid.org/0000-0002-4155-4849)

Smirnova Tatyana L.: Candidate of Medical Sciences, Associate Professor, Department
of Obstetrics and Gynecology, Chuvash State University, Russia, Cheboksary (tlsmr@mail.ru; ORCID: https://orcid.org/0000-0002-8224-1515)

Platonova Kseniya I.: 4th year Student, Chuvash State University, Russia, Cheboksary (ksenya_platonova23@mail.ru; )

Ukhterova Nadezhda D.: Candidate of Medical Sciences, Associate Professor of Internal Medicine Department, Chuvash State University, Russia, Cheboksary (55dd@mail.ru; ORCID: https://orcid.org/0000-0003-1808-6845)

Lutkova Tatyana S.: Candidate of Medical Sciences, Associate Professor of Internal Diseases Department, Chuvash State University, Russia, Cheboksary (lts21@mail.ru; ORCID: https://orcid.org/0000-0003-2368-5084)

Markelova Ludmila L.: Clinical Resident, Postgraduate Doctors' Training Istitute, Russia, Cheboksary (markelovtatyana@yandex.ru; )

Article link

Zhuravleva N.V., Babokin V.E., Barsukova E.V., Karzakova L.M., Fomina R.V., Komelyagina N.A., Smirnova T.L., Platonova K.I., Ukhterova N.D., Lutkova T.S., Markelova L.L. The Effect of COVID-19 on Myocardial Damage: a Clinical Case [Electronic resource] // Acta medica Eurasica. – 2022. – №2. P. 31-39. – URL: https://acta-medica-eurasica.ru/en/single/2022/2/5/. DOI: 10.47026/2413-4864-2022-2-31-39.

Single article

Zhuravleva N.V., Babokin V.E., Barsukova E.V., Karzakova L.M., Fomina R.V., Komelyagina N.A., Smirnova T.L., Platonova K.I., Ukhterova N.D., Lutkova T.S., Markelova L.L.