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Stepanov V.G., Timofeeva L.A., Alekseev S.V., Yusova M.A.
Evaluation of Predictive Capabilities of TIRADS, EU-TIRADS, TLA_RU systems in the Ultrasound Diagnosis of Thyroid Nodular Pathology
Keywords: thyroid gland, nodular masses, multiparametric ultrasound examination, stratification systems TIRADS, EU-TIRADS, TLA_RU
The aim of the study was to evaluate the prognostic capabilities of EU-TIRADS, TIRADS, TLA_RU systems in ultrasound diagnostics of thyroid nodular masses. A retrospective independent continuous blind study of ultrasound examination protocols was conducted in 665 patients, 241 patients had benign non-cancerous thyroid diseases, 86 patients had benign tumors (adenomas), 338 patients had thyroid cancer. During the preoperative examination, all patients underwent a multiparametric ultrasound examination of the neck organs according to the standard procedure, with the registration of identified thyroid nodes, with examining the prognostic capabilities of stratification systems – TIRADS, EU-TIRADS, TLA_RU. It was found that the TIRADS system has a sensitivity of 91.04%, specificity – 91.41%. Focusing on the scale of AUC values reflecting the quality of the diagnostic test, it can be stated that TIRADS is a test with excellent quality (AUC =0.972). Basing on the results of the analyzing the data obtained by the EU-TIRADS system, it was revealed that it is a high-quality test (AUC=0.826), but its predictive capabilities are worse than those of TIRADS. The original TLA_RU model has 87.5% sensitivity and 95.7% specificity. During the ROC analysis, it was found that the AUC is equal to 0.954±0.00894, which suggests that the TLA_RU model is an excellent quality test in the differential diagnosis of thyroid nodular masses. Multivariate statistical comparative analysis of thyroid imaging assessment systems (TIRADS, EU-TIRADS and TLA_RU) from the standpoint of evidence-based medicine has shown that thyroid cancer risk stratification systems based on the assessment of multiparametric ultrasound signs have great diagnostic capabilities.
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About authors
- Stepanov Vladimir G.
- Minister, Ministry of Health of the Chuvash Republic, Russia, Cheboksary (medicin_prm@cap.ru; )
- Timofeeva Lyubov A.
- Doctor of Medical Sciences, Professor, Department of Propedaedeutics of Internal Diseases with Radio Diagnosis Course, Chuvash State University, Russia, Cheboksary (adabai@mail.ru; ORCID: https://orcid.org/0000-0002-4707-8214)
- Alekseev Sergey V.
- Oncologist, Head of Oncological Department No. 2 (Head and Neck Tumors), Republican Clinical Oncology Dispensary, Russia, Cheboksary (rkod@med.cap.ru; )
- Yusova Marina A.
- Post-Graduate Student, Department of Propedaedeutics of Internal Diseases with Radio Diagnosis Course, Chuvash State University, Russia, Cheboksary (yusova2012@mail.ru; ORCID: https://orcid.org/0000-0002-8034-5337)
Article link
Stepanov V.G., Timofeeva L.A., Alekseev S.V., Yusova M.A. Evaluation of Predictive Capabilities of TIRADS, EU-TIRADS, TLA_RU systems in the Ultrasound Diagnosis of Thyroid Nodular Pathology [Electronic resource] // Acta medica Eurasica. – 2021. – №4. P. 29-38. – URL: https://acta-medica-eurasica.ru/en/single/2021/4/4/. DOI: 10.47026/2413-4864-2021-4-29-38.