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Struchko G., Timofeeva N., Mikhailova M., Kostrova O., Stomenskaya I., Bubnova N.
Hematological Parameters of Female Rats in Conditions of Experimental Mammary Carcinogenesis
Keywords: carcinogenesis, peripheral blood, rats, white blood cells
The aim of the work was to study changes in peripheral blood in 24 white non-pedigree female rats during experimental carcinogenesis. The preparation N-methyl-N-nitrosourea, which induces the development of mammary cancer, was used as a carcinogen. The results of hemograms of 8 intact and 16 experimental rats were used. Changes in the number of erythrocytes, platelets, leukocytes, hemoglobin level and leukocyte formula were studied. In addition, leukocytic indices were calculated: the index of white blood cells shift and lymphocytic-granulocytic index. The study showed that the initial stage of tumor process development causes a reaction from the thrombocytic lineage, which is manifested by thrombocytosis. Subsequently, the most pronounced changes occur in the white blood. Leukopenia is observed due to a decrease in the absolute number of lymphocytes, monocytes and granulocytes. No significant changes were found in the red blood shoot.
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About authors
- Стручко Глеб Юрьевич
- доктор медицинских наук, профессор, заведующий кафедрой нормальной и топографической анатомии с оперативной хирургией, Chuvash State University, Russia, Cheboksary (glebstr@mail.ru; ORCID: https://orcid.org/0000-0002-0549-5116)
- Тимофеева Наталья Юрьевна
- старший преподаватель кафедры инструментальной диагностики с курсом фтизиатрии, Chuvash State University, Russia, Cheboksary (bla11blabla@yandex.ru; ORCID: https://orcid.org/0000-0002-7596-0132)
- Михайлова Марина Николаевна
- кандидат медицинских наук, доцент кафедры нормальной и топографической анатомии с оперативной хирургией, Chuvash State University, Russia, Cheboksary (mar3007@mail.ru; )
- Кострова Ольга Юрьевна
- кандидат медицинских наук, заведующая кафедрой инструментальной диагностики с курсом фтизиатрии, Chuvash State University, Russia, Cheboksary (evkbiz@yandex.ru; ORCID: https://orcid.org/0000-0002-7057-9834)
- Стоменская Ирина Станиславовна
- кандидат медицинских наук, доцент кафедры инструментальной диагностики с курсом фтизиатрии, Chuvash State University, Russia, Cheboksary (irina.stomenskaja@gmail.com; ORCID: https://orcid.org/0000-0001-7332-4477)
- Бубнова Наталья Владимировна
- ассистент кафедры инструментальной диагностики с курсом фтизиатрии, Chuvash State University, Russia, Cheboksary (natalia210485@yandex.ru; ORCID: https://orcid.org/0000-0002-2505-0827)
Article link
Struchko G., Timofeeva N., Mikhailova M., Kostrova O., Stomenskaya I., Bubnova N. Hematological Parameters of Female Rats in Conditions of Experimental Mammary Carcinogenesis [Electronic resource] // Acta medica Eurasica. – 2019. – №4. P. 52-53. – URL: https://acta-medica-eurasica.ru/en/single/2019/4/6/.