Single article

Kostrova O., Stomenskaya I., Struchko G., Timofeeva N., Nikiforova N., Sergeeva K., Razbirina E.

Changes in a Myelogram Against the Background of Leukemia

Keywords: acute leukemia, chronic leukemia, myelogram, blood cells, leuko-erythroblastic ratio, neutrophil maturation index

The paper analyzes the results of 136 patients study with various forms of leukemia. Leukemia was detected in 47 women and 89 men. 69 people were diagnosed with acute leukemia, 67 – with chronic one. Among acute forms, myeloblastic leukemia was found in 30,4% of those examined, lymphoblastic – in 14,5%, undifferentiated leukemia – 50,7%, promyelocytic leukemia was detected in 4,3%. Among chronic forms, myelocytic leukemia was detected in 16,4% of patients, lymphocytic leukemia – in 77,6%, and monocytic, hairy cell leukemia and osteomyelofibrosis in one case each. The average age of patients with acute leukemia was 44,9±1,7 years, those with chronic leukemia – 61,1±1,3 years. When calculating various indices in both acute and chronic leukemia, the data turned out to be ambiguous. A decline in the neutrophil maturation index predominated, most likely as a result of cytostatic therapy. A simultaneous increase in the leuko-erythroblastic ratio may indicate a significant dilution of bone marrow punctate.

References

  1. Akhmerzaeva Z.Kh. Epidemiologicheskoe issledovanie ostrykh leikozov v otdel’nykh regionakh Rossiiskoi Federatsii: dis. … kand. med. nauk [Epidemiological study of acute leukemia in some regions of the Russian Federation. Abstract of Diss.]. Moscow, 2018.
  2. Vladimirskaya E.B. Normal’noe krovetvorenie i ego regulyatsiya [Normal hemopoesis and it regulation]. Klinicheskaya onkogematologiya [Clinical oncohemaology], 2015, no. 8(2), pp. 109–119.
  3. Gribova I.A., Vorob’ev P.A. Gematologicheskaya norma [Hematological norm]. In: Vorob’ev I.A., ed. V rukovodstve po gematologii [Manual of Hematology]. Moscow, 2002, vol. 1, pp. 61–63.
  4. Kostrova O.Yu., Timofeeva N.Yu., Struchko G.Yu., Stomenskaya I.S. Anomaliya Pel’gera-Kh’yueta [Anomaly of Pelger-Huet]. Meditsinskii al’manakh [Medical almanac], 2016, no. 2(42), pp. 43–44.
  5. Mustafakulova N.I., Melikova T.I., Mustafakulova N.S. Faktory riska razvitiya i osobennosti klinicheskogo techeniya leikozov v respublike Tadzhikistan [Risk factors and features of the clinical course of leukemia in the Republic of Tajikistan]. Vestnik Avitsenny [Avicenna’s Bulletin], 2015, no. 1(62), pp. 67–71.
  6. Mukhtarov T.A., Skvortsov V.V. Ostrye leikozy: sovremennye metody diagnostiki [Acute leukemia: modern methods of diagnosis]. Poliklinika [Polyclinic], 2016, no. 6, pp. 40–42.
  7. Nikolaeva L.P., Cherdantsev D.V., Khvat N.S. Osobennosti mielogrammy kostnogo mozga trubchatykh kostei [Features of the myelogram of the bone marrow of tubular bones]. Sovremennye problemy nauki i obrazovaniya [Modern problems of science and education], 2015, no. 4, p. 378.
  8. Pavlova G.P., Suslonova N.V., Zhukovskaya E.V., Rumyantsev A.G. Epidemiologicheskaya kharakteristika boleznei krovi u detei Chuvashskoi Respubliki [Epidemiological characteristics of blood diseases in children of Chuvash Republic]. Voprosy prakticheskoi pediatrii [Questions of practical Pediatrics], 2015, vol. 10, no. 1, pp. 79–86.
  9. Saifeeva A.A. Patofiziologiya leikozov [Pathophysiology of leukemia]. Alleya nauki [Alley of science], 2017, vol. 2, no. 11, pp. 17–18.
  10. Teplyakova E.D., Savis’ko A.A., Aslanyan K.S. Zabolevaemost’ ostrymi leikozami u detei rostovskoi oblasti za period 1991–2010 gg [Leukemia morbidity in children of the Rostov region for the period of 1991–2010]. Fundamental’nye issledovaniya [Fundamental research], 2012, no. 2-2, pp. 363–367.
  11. Frenkel’A. Issledovanie kostnogo mozga v onkologii [Bone marrow research in oncology]. Immunologiya gemopoeza [Immunology of hemopoesis], 2014, vol. 12, no. 1-2, pp. 18-41.
  12. Khachirov D.G., Kazieva Kh.E., Dzhalilova N.A., Ataev M.G. Vozrastnye i gendernye aspekty smertnosti ot leikozov v gorodakh i sel’skoi mestnosti [Age and gender aspects of mortality from leukemia in urban and rural areas]. Vestnik Dagestanskoi gosudarstvennoi meditsinskoi akademii [Bulletin of the Dagestan state medical Academy], 2012, no. 4, pp. 36–43.
  13. Chesnokova N.P., Zhevak T.N., Nevvazhai T.A., Polutova N.V., Bizenkova M.N. Lektsiya 1. Leikozy: etiologiya i patogenez, obshchie zakonomernosti razvitiya [Lecture 1: Leukemia: etiology and pathogenesis, general patterns of development]. Mezhdunarodnyi zhurnal prikladnykh i fundamental’nykh issledovanii [International journal of applied and fundamental research], 2015, no. 7-1, pp. 161–163.
  14. Chugunova I.P., Valeeva G.K., Vasil’eva A.I., Petrova N.A., Chernova A.I., Bagil’dinskaya M.V., Gorbunova N.N., Markizova L.A. Znachenie analiza na mielogrammu u gematologicheskikh bol’nykh [The value of myelogram analysis in hematological patients]. Molodoi uchenyi [Young researcher], 2018, no. 9(195), pp. 64–68.
  15. Martinez-Leborans L., Victoria-Martinez A.M., Torregrosa-Calatayaud J.L., Alegre de Miquel V. Leukemia Cutis: A Report of 17 Cases and a Review of the Literature. Actas Dermosifiliogr., 2016, no. 107(9), p. 65–69.
  16. Ren Y., Fu R., Qu W., Ruan E., Wang X., Wang G., Wu Y., Liu H., Song J., Guan J., Xing L., Li L., Wang H., Shao Z. Clinical analysis of 70 cases of polycythemia vera. Zhonghua Yi Xue Za Zhi, 2015, no. 95(18), pp. 1378–138.

About authors

Kostrova Olga Yu.
Candidate of Medical Sciences, Assistant Professor, Head of Department of the Instrumental Diagnostics with a Course of Phthisiology, Chuvash State University, Russia, Cheboksary (evkbiz@yandex.ru; ORCID: https://orcid.org/0000-0002-7057-9834)
Stomenskaya Irina S.
Candidate of Medical Sciences, Assistant Professor, Department of the Instrumental Diagnostics with a Course of Phthisiology, Chuvash State University, Russia, Cheboksary (irina.stomenskaja@gmail.com; ORCID: https://orcid.org/0000-0001-7332-4477)
Struchko Gleb Yu.
Doctor of Medical Sciences, Professor, Head of Normal and Topographic Anatomy Department, Chuvash State University, Russia, Cheboksary (glebstr@mail.ru; ORCID: https://orcid.org/0000-0002-0549-5116)
Timofeeva Natalya Yu.
Senior Lecturer, Department of Instrumental Diagnostics Department with a Course of Phthisiology, Chuvash State University, Russia, Cheboksary (bla11blabla@yandex.ru; ORCID: https://orcid.org/0000-0002-7596-0132)
Nikiforova Natalya Valeryevna
Centralized Clinical Diagnostic Laboratory head, Republican Clinical Hospital, Russia, Cheboksary )
Sergeeva Kristina Yurievna
Central Clinical Diagnostic Laboratory clinical laboratory diagnostics doctor, Republican Clinical Hospital, Russia, Cheboksary )
Razbirina Ekaterina A.
Student of Medical Faculty, Chuvash State University, Russia, Cheboksary (razbirinae@mail.ru; )

Article link

Kostrova O., Stomenskaya I., Struchko G., Timofeeva N., Nikiforova N., Sergeeva K., Razbirina E. Changes in a Myelogram Against the Background of Leukemia [Electronic resource] // Acta medica Eurasica. – 2019. – №2. P. 44-51. – URL: https://acta-medica-eurasica.ru/en/single/2019/2/6/.