Single article

Kudryashov S., Leontyeva E., Karzakova L.

The modern features of clinical and immunological manifestations of glomerulonephritis

Keywords: glomerulonephritis, immune status, immunodepression

The research objective was to study the features of the clinical picture and the immune response in patients with glomerulonephritis (GN). The research included the retrospective analysis of clinical records of patients with GN (n = 1381) who received hospitalization in the nephrologic department of the Republican Clinical Hospital of the Ministry of Health of the Chuvash Republic in 2010–2015, and definition of indicators of the innate and adaptive immune responses in 116 patients with GN staying on the stationary office in the same department. As a result of the research it has been established that currently GN has a low-symptom course. Currently GN is characterized by a low-symptom course or lack of clinical manifestations in its early stages, which makes the diagnosis of the disease untimely in 3,4±0,49% of cases. A tenth of patients undergoes transformation of latent GN in clinically manifested variants of the disease (nephrotic, hypertonic and mixed) after 17,4±2,3 months from the moment of laboratory manifestation of the disease. GN is associated with changes in the immune status according to the type of activation of the humoral component against the background of depression of other components of the immune defense.


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About authors

Karzakova Luiza M.
Doctor of Medical Sciences, Professor, Head of Internal Diseases Department, Chuvash State University, Russia, Cheboksary (; ORCID:
Kudryashov Sergei I.
Candidate of Medical Sciences, Assistant Lecturer of Internal Diseases Department, Chuvash State University, Russia, Cheboksary (; ORCID:
Leontieva Ekaterina Viktorovna
nephrology unit head, Republican Clinical Hospital, Russia, Cheboksary (; )

Article link

Kudryashov S., Leontyeva E., Karzakova L. The modern features of clinical and immunological manifestations of glomerulonephritis [Electronic resource] // Acta medica Eurasica. – 2017. – №2. P. 13-18. – URL: