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Speranskaya E., Mukhamedzhanova L., Golubtsova N.
Morphological assessment of proliferative processes activity in periodontal tissues in patients with chronic generalized periodontitis
Keywords: chronic generalized periodontal disease, Ki-67, proliferative activity, markers
The purpose of work consisted in studying morphological structures of multilayer flat gum epithelium in chronic generalized periodontal disease. Tissue of gingival papilla of 55 patients was studied by means of immunohistochemical methods. Proliferative cellular activity of multilayer flat epithelium and that of proper gingival plate was determined by Ki-67 marker’s expression level. It is established that in inflammatory-destructive lesions proliferative activity of epitheliocytes decresases by 1,4, that of proper gingival plate fibroblasts – more than twice. When staining with hematoxylin and eosine it is noted that in patients with an intact parodentium, mucous membrane proper plate has indistinctly expressed papillary and reticular layer in comparison with patients burdened by periodontal disease: the number of connective tissue papillas increases by 1,2. Chronic inflammation in parodontal tissues leads to change in cytoarchitecture and cellular proliferative activity in gingival papilla.
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About authors
- Speranskaya Ekaterina Mikhailovna
- dental diseases propedeutics and new technologies department assistant, Chuvash State University, Russia, Cheboksary (katerina_dumspirospero@mail.ru; )
- Mukhamedzhanova Lyubov R.
- Doctor of Medical Sciences, Professor, Department of Propaedeutics of Dental Diseases and New Technologies, Chuvash State University, Russia, Cheboksary (lr71@bk.ru; ORCID: https://orcid.org/0000-0003-0752-6497)
- Golubtsova Natalya Nikolaevna
- candidate of biological sciences, associate professor, general and clinical morphology and forensic medicinee department head, Chuvash State University, Russia, Cheboksary (golubnata@list.ru; )
Article link
Speranskaya E., Mukhamedzhanova L., Golubtsova N. Morphological assessment of proliferative processes activity in periodontal tissues in patients with chronic generalized periodontitis [Electronic resource] // Acta medica Eurasica. – 2017. – №1. P. 55-59. – URL: https://acta-medica-eurasica.ru/en/single/2017/1/9/.