Single article

Mukhamedzhanova L., Egorov M.

Impact of indicators of regenerative potential defects in the epithelization of the mucous membrane and red lip line

Keywords: regenerative potential biomarker Ki-67, epithelization of chronic crack of the lips, chronic crack of the lip

The purpose of the work was to study the causes of chronic crack of the lip, as well as to identify factors involved in the chronicity of the process. With the help of immunohisto-chemical methods there were studied 70 patients (biopsy samples from the surface of the lips) to determine the degree of expression of the biomarker Ki-67 as an indicator of regenerative potential of epithelial cells of red lip line. It was found that patients burdened inflammatory and destructive periodontal disease, that have plush lips, the presence of traumatic agent in the oral cavity against the lips are more prone to chronic cracked lips. It was revealed that the highest rate of the biomarker Ki-67 in tissues of the red lip line of the lips gives an indication of the high regenerative potential, but there is a «red zone», after which the process should be seen as a sign of malignant transformation.


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About authors

Mukhamedzhanova Lyubov R.
Doctor of Medical Sciences, Professor, Department of Propaedeutics of Dental Diseases and New Technologies, Chuvash State University, Russia, Cheboksary (; ORCID:
Egorov Mikhail A.
Candidate of Medical Sciences, Assistant Lecturer, Department
of Рropeаdeutics of Dental Diseases and New Technologies, Chuvash State University, Russia, Cheboksary (; )

Article link

Mukhamedzhanova L., Egorov M. Impact of indicators of regenerative potential defects in the epithelization of the mucous membrane and red lip line [Electronic resource] // Acta medica Eurasica. – 2016. – №1. P. 23-28. – URL: