Статья журнала

Козлов В.А., Сапожников С.П., Голенков А.В., Шептухина А.И., Николаева О.В.

Амилоид – это плохо? Амилоид с точки зрения супрамолекулярной химии

Ключевые слова: амилоид, нанотрубки, супрамолекулярные взаимодействия, параметаболизм

Амилоидная болезнь и процесс амилоидообразования рассмотрены с точки зрения супрамолекулярной химии и адаптационной теории. Сделан вывод, что амилоидоз – саногенетическая реакция, приводящая к болезни в силу избыточности молекулярного ответа. Мы предполагаем, что белки-предшественники амилоида вступают в супрамолекулярное взаимодейстие с образованием нанотрубок, только попав в неблагоприятное ионно-молекулярное окружение. Истинная роль синтеза белков-предшественников амилоида при врожденной или приобретенной хронической воспалительной патологии остается неизвестной. Ставится вопрос о необходимости выяснения физиологической роли амилоидных фрагментов.

Kozlov V., Sapozhnikov S., Golenkov A., Sheptukhina A., Nikolaeva O.

Amiloid – it is bad? AMiloid from the point of view of supramolecular chemistry

Keywords: amiloid, nanotubes, supramolecular interactions, parametabolism

The Amiloid illness and process formation of an amiloid are considered from the point of view of supramolecular chemistry and the adaptation theory. The conclusion that amiloidos – the sanogenetic reaction leading to an illness owing to redundancy of the molecular answer is drawn. We assume that squirrels predecessors of an amiloid enter in supramolecular interaction with formation of nanotubes only having got to an adverse ion-molecular environment. What true role of synthesis of proteins of predecessors of an amiloid at the congenital or acquired chronic inflammatory pathology remains to unknown. The question of need of clarification of a physiological role the amiloid of fragments is raised.

Литература

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  30. Koudinov A.R., Berezov T.T., Koudmova N.V. The Levels of Soluble Amyloid Beta in Different High Density Lipoprotein Subfractions Distinguish Alzheimer’s and Normal Aging Cerebrospinal Fluid Implication for Brain Cholesterol Pathology. Lett., 2001, vol. 314, pp. 115–118.
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  43. Plant D., Boyle J.P., Smith I.F., Peers C., Pearson H.A. The production of amyloid beta peptide is a critical requirement for the viability ofcentral neurons. J. Neurosci., 2003, vol. 23, pp. 5531–5535.
  44. Romhányi G. Selective demonstration of amyloid deposits and methodical possibilities of analysis of their ultrastructural differences. Allg. Pathol., 1979, vol. 123, no. 1-2, pp. 9–16.
  45. Rothbard J.B., Zhao X., Sharpe O., Strohman M.J., Kurnellas M., Mellins E.D., Robinson W.H., Steinman L. Chaperone activity of α,β-crystallin is responsible for its incorrect assignment as an autoantigen in multiple sclerosis. Immunol., 2011, vol. 186, no. 7, pp. 4263–4268.
  46. Sawaya M.R., Sambashivan S., Nelson R., Ivanova M.I., Sievers S.A., Apostol M.I., Thompson M.J., Balbirnie M., Wiltzius Jed J. W., McFarlane H.T., Madsen A., Riekel C., Eisenberg D. Atomic structures of amyloid cross-β spines reveal varied steric zippers. Nature, 2007, vol. 447, pp. 453–457.
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Сведения об авторах

Козлов Вадим Авенирович
доктор биологических наук, кандидат медицинских наук, профессор кафедры медицинской биологии с курсом микробиологии и вирусологии, Чувашский государственный университет, Россия, Чебоксары (pooh12@yandex.ru)
Сапожников Сергей Павлович
доктор медицинских наук, профессор, заведующий кафедрой медицинской биологии с курсом микробиологии и вирусологии, Чувашский государственный университет, Россия, Чебоксары (adaptogon@mail.ru)
Голенков Андрей Васильевич
доктор медицинских наук, профессор, заведующий кафедрой психиатрии, медицинской психологии и неврологии, Чувашский государственный университет, Россия, Чебоксары (golenkovav@inbox.ru)
Шептухина Алена Игоревна
студентка VI курса медицинского факультета, Чувашский государственный университет, Россия, Чебоксары (priffetik@bk.ru)
Николаева Оксана Владиславовна
клинический ординатор кафедры психиатрии, медицинской психологии и неврологии, Чувашский государственный университет, Россия, Чебоксары (lovely667@mail.ru)

Ссылка на статью

Козлов В.А., Сапожников С.П., Голенков А.В., Шептухина А.И., Николаева О.В. Амилоид – это плохо? Амилоид с точки зрения супрамолекулярной химии [Электронный ресурс] // Acta medica Eurasica. – 2016. – №1. – С. 50-60. – URL: http://acta-medica-eurasica.ru/single/2016/1/7/.