Single article

Merkulova l., Struchko G., Arlashkina O., Mikhaylova M.

Morfological changes of the lien in the conditions of the experimental carcinogenesis

Keywords: lien, carcinogenesis, 1, 2-dimethylhydrazine, B-lymphocytes, T-lymphocytes, white pulp, tumor, colon

By means of morphological and immunohistochemical methods of a research the lymphoid device of a lien at rats at the age of 3 and 6 months which underwent a chemical carcinogenesis, the induced 1,2-dimetilgidraziny is studied. It is established that the entered carcinogen leads to decrease of the main morphometric indicators In - and T-dependent zones of a lien. After administration of carcinogen in these zones the number of CD79α+ cells (B-lymphocytes) and CD45RO+ cells (T-lymphocytes) is considerably reduced. It is taped that all quantitative and high-quality changes of a white pulp of a lien are more expressed at rats at the age of 6 months.

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About authors

Struchko Gleb Yu.
Doctor of Medical Sciences, Professor, Head of Normal and Topographic Anatomy Department, Chuvash State University, Russia, Cheboksary (glebstr@mail.ru)
Arlashkina Olga Mikhailovna
instrumental diagnostics with the course of phthisiology department graduate student, Chuvash State University, Russia, Cheboksary (olgaruz1202@mail.ru)
Mikhailova Marina A.
Candidate of Medical Sciences, Assistant Professor, Normal and Topographic Anatomy Department, Chuvash State University, Russia, Cheboksary (mar3007@mail.ru)
Merkulova Larisa M.
Doctor of Medical Sciences, Professor of Normal and Topographic Anatomy Department, Chuvash State University, Russia, Cheboksary (merkulova192@mail.ru)

Article link

Merkulova l., Struchko G., Arlashkina O., Mikhaylova M. Morfological changes of the lien in the conditions of the experimental carcinogenesis [Electronic resource] // Acta medica Eurasica. – 2016. – №3. P. 54-58. – URL: http://acta-medica-eurasica.ru/en/single/2016/3/9/.