Radionuclide lymphoscintigraphy in modern diagnosis of chro ic venous insufficiency

DOI: 10.47026/2413-4864-2026-1-76-90

UDC: 616.428-073.7:617.58:612.134
BBC: 53.64+54.102.3

Fomina E.E., Chesnokova A.S., Bashirov R.A., Ryzhkin S.A., Ziganshina L.F., Samoylenko L.E.

Radionuclide lymphoscintigraphy in modern diagnosis of chro ic venous insufficiency

Keywords: radiation diagnostics, lymphoscintigraphy, technetium-99m, lymphatic insufficiency; phlebolymphedema

The review systematizes modern concepts and substantiates the role of radionuclide lymphoscintigraphy in assessing the lymphatic component in chronic venous insufficiency of the lower extremities. Given the limitations of anatomically oriented techniques (ultrasound diagnostics, magnetic resonance lymphangiography, and indocyanine green fluorescence lymphography), radionuclide lymphoscintigraphy provides a reproducible assessment of lymphatic drainage, detects early abnormalities, distinguishes between venous and lymphatic contributions to the development of edemas, and enables to monitor the effect of therapy. Special attention is paid to the preparation 99mTc-Nanotope as a widely used nanocolloidal radiopharmaceutical with optimal physico-chemical characteristics for quantitative radionuclide lymphoscintigraphy, as well as issues of results comparability when using alternative preparations. The key scintigraphic signs of lymphatic dysfunction are systematized and their clinical significance is analyzed. Integration of radionuclide lymphoscintigraphy into examination algorithms for chronic venous insufficiency increases the accuracy of phlebolymphedema verification and supports personalized treatment choice.

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About authors

Fomina Elena E.: Doctor of Medical Sciences, Professor, Department of Ultrasound Diagnostics, Kazan State Medical Academy – Branch Campus of the Russian Medical Academy of Continuous Professional Education, Russia, Kazan (eefomina@mail.ru; ORCID: https://orcid.org/0000-0003-0667-6127)

Chesnokova Anna S.: Resident Physician, N.N. Blokhin Russian Cancer Research Center, Russia, Moscow (anatchesnockowa@yandex.ru; )

Bashirov Rustem A.: Assistant Professor, Department of Radiology, Radiotherapy, Radiation Hygiene and Radiation Safety named after Academicians A.S. Pavlov and F.G. Krotkov; Assistant Lecturer, Department of Oncology, Radiation Diagnostics and Radiation Therapy, Kazan State Medical University, Russia, Kazan (bashirov6939@gmail.com; ORCID: https://orcid.org/0000-0002-0128-5605)

Ryzhkin Sergey A.: Doctor of Medical Sciences, Corresponding Member, Tatarstan Academy of Sciences, Russia, Kazan; Head of the Department of Radiology, Radiotherapy, Radiation Hygiene and Radiation Safety named after Academicians A.S. Pavlov and F.G. Krotkov, Russian Medical Academy of Postgraduate Education, Russia, Moscow; Professor, Department of General Hygiene, Kazan State Medical University, Russia, Kazan; Professor, Department of Medical Physics, Institute of Physics, Kazan (Volga Region) Federal University, Russia, Kazan (rsa777@inbox.ru; ORCID: https://orcid.org/0000-0003-2595-353X)

Ziganshina Lilia F.: Candidate of Medical Sciences, Associate Professor, Department of Oncology, Radiation Diagnostics and Radiation Therapy, Kazan State Medical University, Russia, Kazan (zig.lilia@yandex.ru; ORCID: https://orcid.org/0009-0001-2744-6219)

Samoylenko Lyudmila E.: Doctor of Medical Sciences, Department of Radiology, Radiotherapy, Radiation Hygiene and Radiation Safety named after Academicians A.S. Pavlov and F.G. Krotkov, Russian Medical Academy of Postgraduate Education, Russia, Moscow (lesamoylenko@gmail.com; )

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Fomina E.E., Chesnokova A.S., Bashirov R.A., Ryzhkin S.A., Ziganshina L.F., Samoylenko L.E. Radionuclide lymphoscintigraphy in modern diagnosis of chro ic venous insufficiency [Electronic resource] // Acta medica Eurasica. – 2026. – №1. P. 76-90. – URL: https://acta-medica-eurasica.ru/en/single/2026/1/8/. DOI: 10.47026/2413-4864-2026-1-76-90.

Single article

Fomina E.E., Chesnokova A.S., Bashirov R.A., Ryzhkin S.A., Ziganshina L.F., Samoylenko L.E.