Single article

DOI: 10.47026/2413-4864-2026-1-67-75

Skvortsova E.N., Efremova A.V., Zyulkina L.A., Frolova K.E., Zhadanova N.V., Karayan A.V.

The relationship of phys ological aging of the body with somatic diseases and pathology of the dento-facial system

Keywords: caries, immunity, salivary glands, saliva, old age, osteoporosis, parodontitis

The analysis of modern literature on peculiarities of caries and parodontitis development process in people over 60 years of age is presented. The relationship between destructive changes in the hard dental tissues, parodontal lesions and age-related changes in organs and body systems is considered. The purpose of the review is to analyze the relationship of physiological aging of the body with somatic diseases and pathology of the dento-facial system based on the data of modern literature. A prolonged inflammatory process in parodontium leads to gum tissue recession, exposure of the anatomical neck of the teeth and caries development. Prolonged ignoring the symptoms of parodontitis leads to abnormal tooth loosening and the need for tooth extraction. Thus, this raises the issue of secondary edentulism in elderly patients. Occlusion disturbance caused by missing teeth leads to impaired chewing function and a change in diet towards a diet dominated by soft foods rich in carbohydrates and saturated fats, which contributes to the development of cardiovascular diseases. A systematic literature search was performed using the eLibrary and PubMed databases. The request for "The connection between physiological aging of the body and somatic diseases and pathology of the dental system" received 1,567 publications. 51 sources of Russian and foreign literature were selected, review and original articles were studied. It was found that the most common pathologies in the dental system in elderly patients are dystrophic and inflammatory processes in parodontal tissues, combined with caries, which can subsequently lead to the development of secondary adentia. Hence, a thorough investigation of the aetiology and pathogenesis of dental caries and its correlation with the general somatic health of elderly patients is required.

References

  1. Afanas’ev V.V., Mirzakulova U.R. Slyunnye zhelezy. Bolezni i travmy [Salivary Glands. Diseases and Injuries]. Moscow, GEOTAR-Media Publ., 2019, 320 p.
  2. Benevolevskaya L.I., Lesnyak O.M. Diagnostika, profilaktika i lechenie. Klinicheskie rekomendatsii Rossiiskoi assotsiatsii po osteoporozu. 2-e izd. [Diagnosis, Prevention and Treatment. Clinical Guidelines of the Russian Association on Osteoporosis. 2nd]. Moscow, GEOTAR-Media Publ., 2010, 272 p.
  3. Severin S., ed. Biokhimiya. 5-e izd. [Biochemistry. 5th ed.]. Moscow, GEOTAR-Media Publ., 2015, 768 p.
  4. Mamadzhonova Sh.G., Gal’chinskaya P.S., Bogdanova S.E. et. al. Vozrastnye osobennosti slyunnykh zhelez cheloveka [Age-Related Features of Human Salivary Glands]. Mezhdunarodnyi zhurnal eksperimental’nogo obrazovaniya, 2016, no. 5-3, pp. 388–389.
  5. Mikhal’chenko V.F., Kraynov S.V., Yakovlev A.T. et al. Dinamika pokazatelei mestnogo immuniteta pri lechenii khronicheskogo generalizovannogo parodontita u lits pozhilogo vozrasta [Dynamics of Local Immunity Indicators During Treatment of Chronic Generalized Periodontitis in Elderly Individuals]. Sovremennye problemy nauki i obrazovaniya, 2015, no. 6, pp. 34.
  6. Ilyunina O.O. Retsessiya desny: sovremennoe sostoyanie voprosa (obzor literatury) [Gingival Recession: Current State of the Issue (Literature Review)]. Izvestiya vysshikh uchebnykh zavedenii. Povolzhskii region. Meditsinskie nauki, 2024, no. 4, pp. 5–19. DOI: 10.21685/2072-3032-2024-4-1.
  7. Ippolitov E.V., Klemin V.A. Immunologicheskie aspekty patogeneza vospalitel’nykh zabolevanii parodonta [Immunological Aspects of the Pathogenesis of Inflammatory Periodontal Diseases]. Stomatologiya, 2017, no. 5, pp. 73–77.
  8. Kostyaeva M.G., Eremina I.Z., Kastyro I.V. Morfologiya i fiziologiya slyunnykh zhelez [Morphology and Physiology of Salivary Glands]. Head and neck. Golova i sheya. Russian Journal, 2022, vol. 10, no. 3, pp. 81–87.
  9. Miklyaev S.V., Leonova O.M., Sushchenko A.V. et al. Mikrobiologicheskii peizazh parodontal’nogo karmana pri vospalitel’nykh zabolevaniyakh v tkanyakh parodonta [Microbiological Landscape of the Periodontal Pocket in Inflammatory Periodontal Tissue Diseases]. Vestnik Rossiiskogo universiteta druzhby narodov. Ser. Meditsina, 2021, vol. 25, no. 4, pp. 332–338. DOI: 10.22363/2313-0245-2021-25-4-332-338.
  10. Lesnyak O.M., Benevolevskaya L.I., eds. 2-e izd. [Osteoporosis. 2nd ed.]. Moscow, GEOTAR-Media Publ., 2011, 272 p.
  11. Skvortsova E.N., Senzhapova N.I., Efremova A.V. et al. Osobennosti techeniya kariesa kornya u lits pozhilogo vozrasta [Features of the Course of Root Caries in the Elderly]. Vyatskii meditsinskii vestnik, 2024, vol. 83, pp. 89–93. DOI: 10.24412/2220-7880-2024-3-89-93.
  12. Yanushevich O.O., Dmitrieva A., eds. Parodontologiya [Periodontology]. Moscow, GEOTAR-Media Publ., 2018, 752 p.
  13. Semenov A.A., Vorob’yeva Yu.B., Semenova D.D. Osobennosti lecheniya tverdykh tkaney zubov s uchetom anatomo-funktsional’nykh izmenenii u lits pozhilogo vozrasta [Features of Treatment of Dental Hard Tissues Considering Anatomical and Functional Changes in the Elderly]. St. Petersburg, Lema Publ., 2024, 61 p.
  14. Smetnik V.P., Chernova T.G. Osteoporoz i menopauza [Osteoporosis and Menopause]. Osteoporoz i osteopatii, 2017, no. 3, pp. 20–25.
  15. Tkacheva O.N., Babenko I.V., Vorob’yeva N.M. et al. Sovremennaya geriatriya dlya vrachei pervichnogo zvena: metodicheskoe posobie dlya vrachei pervichnogo zvena zdravookhraneniya [Modern Geriatrics for Primary Care Physicians: A Methodological Guide for Primary Healthcare Physicians]. Moscow, Prometei Publ., 2021, 172 p.
  16. Dmitrieva L.A., ed. Terapevticheskaya stomatologiya [Therapeutic Dentistry]. Moscow, MEDpress-inform Publ., 2016, 896 p.
  17. Dmitrieva A., ed. Terapevticheskaya stomatologiya: natsional’noe rukovodstvo [Therapeutic Dentistry: A National Guide]. Moscow, GEOTAR-Media Publ., 2022, 896 p.
  18. Shamanskikh A.S. Vospalitel’nye protsessy zabolevanii parodonta: etiologiya, obshchie i mestnye faktory (obzor literatury) [Inflammatory Processes in Periodontal Diseases: Etiology, General and Local Factors (Literature Review)]. Molodoi uchenyi, 2020, vol. 296, no. 6, pp. 100–104.
  19. Yanushevich O.O., Kulazhenko T.V. Gerontologicheskie aspekty stomatologicheskoi patologii [Gerontological Aspects of Dental Pathology]. Klinicheskaya stomatologiya, 2019, no. 3, pp. 18–22.
  20. Affoo R.H., Foley N., Garrick R. Meta-analysis of salivary flow rates in young and older adults. J Am Geriatr Soc, 2015, vol. 63, no. 10, pp. 2142–2151. DOI: 10.1111/jgs.13652.
  21. Akbar A.N., Henson S.M. Are senescence and exhaustion intertwined or unrelated processes that compromise immunity? Nature Reviews Immunology, 2021, vol. 21, no. 9, pp. 571–581. DOI: 10.1038/nri2959.
  22. Baker J.L., Bor B., Agnello M., et. al. Ecology of the Oral Microbiome: Beyond Bacteria. Trends Microbiol, 2017, vol. 25, pp. 362– DOI: 10.1016/j.tim.2016.12.012.
  23. Castelo-Branco C., Soveral I. The immune system and aging: a review. Gynecol Endocrinol, 2014, vol. 30, no. 1, pp. 16–22. DOI: 10.3109/09513590.2013.852531.
  24. Chapple I.L.C., Bouchard P., Cagetti M.G. Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases. J Clin Periodontol, 2017, vol. 44, pp. 39–51. DOI: 10.1111/jcpe.12685.
  25. Chaudhury N.M.A., Shirlaw P., Pramanik R. Clinical variations in salivary composition in healthy individuals and patients with xerostomia. J Oral Pathol Med, 2015, vol. 44, no. 8, pp. 587–594.
  26. Compston J.E., McClung M.R., Leslie W.D. Osteoporosis. The Lancet, 2019, vol. 10169, no. 393, pp. 364–376. DOI: 10.1016/S0140-6736(18)32112-3.
  27. Darveau R.P. Periodontitis: a polymicrobial disruption of host homeostasis. Nat Rev Microbiol, 2010, vol. 8, no. 7, pp. 481–490. DOI: 10.1038/nrmicro2337.
  28. Dawes C., Pedersen A.M.L., Villa A. The functions of human saliva: A review sponsored by the World Workshop on Oral Medicine VI. Arch Oral Biol, 2015, vol. 60, no. 6, pp. 863–874. DOI: 10.1016/j.archoralbio.2015.03.004.
  29. Drake M.T., Clarke B.L., Lewiecki E.M. The pathophysiology and treatment of osteoporosis. Clin Ther, 2015, vol. 37, no. 8, pp. 1837–1850. DOI: 1016/j.clinthera.2015.06.006.
  30. Ebersole J.L., Dawson D.R., Morford L.A. Periodontal disease immunology: ‘double indemnity’ in protecting the host. Periodontol 2000, 2013, vol. 62, no. 1, pp. 163–202. DOI: 10.1111/prd.12005.
  31. Fejerskov O., Nyvad B., Kidd E.A. Dental caries: the disease and its clinical management. 3rd  Wiley-Blackwell, 2015, 480 p.
  32. Frenkel E.S., Ribbeck K. Salivary mucins in host defense and disease prevention. J Oral Microbiol, 2015, vol. 7, 29759. DOI: 10.3402/jom.v7.29759.
  33. Furman D., Campisi J., Verdin E. et al. Chronic inflammation in the etiology of disease across the life span. Nature Medicine, 2022, vol. 28, no. 9, pp. 1822–1832. DOI: 10.1038/s41591-019-0675-0.
  34. Hayes M., Burke F., Allen P.F. Incidence, prevalence and global distribution of root caries. Monogr Oral Sci, 2017, vol. 26, pp. 1–8. DOI: 10.1159/000479301.
  35. Haynes L. Aging of the Immune System: Research Challenges to Enhance the Health Span of Older Adults. Front Aging, 2020, vol. 15, pp. 602–608. DOI: 10.3389/fragi.2020.602108.
  36. Lockhart P.B., Bolger A.F., Papapanou P.N. et al. Periodontal Disease and Atherosclerotic Vascular Disease: Does the Evidence Support an Independent Association? Circulation, 2021, vol. 143, no. 7, pp. 739–741. DOI: 10.1161/CIR.0b013e31825719f3.
  37. Lоpez-Pintor R.M., Casañas E., González-Serrano J. Xerostomia, hyposalivation, and salivary flow in diabetes patients. J Diabetes Res, 2016, vol. 2016, pp. 837–842. DOI: 10.1155/2016/4372852.
  38. Lynch C.D., Smith P.W., Cao N. The relationship between root caries and oral health status. Gerodontology, 2018, vol. 35, no. 4, pp. 283–291.
  39. Lynge Pedersen A.M., Belstrоm D. The role of natural salivary defences in maintaining a healthy oral microbiota. J Dent, 2019, vol. 80, pp. 3–12. DOI: 10.1016/j.jdent.2018.08.010.
  40. McClung M.R. Using Osteoporosis Therapies in Combination. Curr Osteoporos Rep, 2017, 15, pp. 343–352. DOI: 10.1007/s11914-017-0376-x.
  41. Mittelbrunn M., Kroemer G. Hallmarks of T cell aging. Nature Immunology, 2021, vol. 22, no. 6, pp. 687–698. DOI: 10.1038/s41590-021-00927-z.
  42. Pedersen A.M.L., Sоrensen C.E., Proctor G.B. Salivary secretion in health and disease. J Oral Rehabil, 2018, vol. 45, no. 9, pp. 730–746. DOI: 10.1111/joor.12664.
  43. Peres M.A., Macpherson L.M.D., Weyant R.J. et. al. Oral diseases: a global public health challenge. Lancet, 2019, vol. 10194, pp. 249–260. DOI: 10.1016/S0140-6736(19)31146-8.
  44. Proctor G.B. The physiology of salivary secretion. Periodontol 2000, 2016, vol. 70, pp. 11–25. DOI: 10.1111/prd.12116.
  45. Rabelo C.C., Melo R.F., França G.M., et al. Accuracy of the Periodontal Screening and Recording (PSR) Index in the context of the 2017 classification of periodontal diseases. Journal of Clinical Periodontology, 2023, vol. 50, no. 5, pp. 612–620.
  46. Ritter A.V., Shugars D.A., Bader J.D. Root caries risk indicators: a systematic review of risk models. Community Dent Oral Epidemiol, 2019, vol. 38, no. 5, pp. 383–397.
  47. Sanz M., Del Castillo A.M., Jepsen S. et al. Periodontitis and Cardiovascular Diseases. Consensus Report. Glob Heart, 2020, vol. 15, no. 1, pp. 1–5.
  48. Shaw A.C., Joshi S., Greenwood H. Aging of the innate immune system. Curr Opin Immunol, 2010, vol. 22, no. 4, pp. 507–513. DOI: 10.1016/j.coi.2010.05.003.
  49. Tоthovа L., Celec P. Oxidative stress and antioxidants in the diagnosis and therapy of periodontitis. Front Physiol, 2017, vol. 8, p. 1055. DOI: 10.3389/fphys.2017.01055.
  50. Tramini P., Montal S., Valcarcel J. Tooth loss and associated factors in long-term institutionalised elderly patients. Gerodontology, 2007, vol. 24, pp. 196–203. DOI: 10.1111/j.1741-2358.2007.00183.x.
  51. Villa A., Connell C.L., Abati S. Diagnosis and management of xerostomia and hyposalivation. Ther Clin Risk Manag, 2015, vol. 11, pp. 45–51. DOI: 10.2147/TCRM.S76282.

About authors

Skvortsova Elena N.
Senior Lecturer, Department of Dentistry, Penza State University, Russia, Penza (len.skvortzova2014@yandex.ru; ORCID: https://orcid.org/0000-0002-0984-2488)
Efremova Anastasia V.
Candidate of Medical Sciences, Associate Professor, Department of Dentistry, Penza State University, Russia, Penza (nastasya.efremova.87@list.ru; ORCID: https://orcid.org/0000-0002-5678-1104)
Zyulkina Larisa A.
Doctor of Medical Sciences, Associate Professor, Dean of the Faculty of Dentistry, Head of the Department of Dentistry, Penza State University, Russia, Penza (larisastom@yandex.ru; ORCID: https://orcid.org/0000-0002-2938-3063)
Frolova Kristina E.
Senior Lecturer, Department of Dentistry, Penza State University, Russia, Penza (kristina.frolova.1983@mail.ru; ORCID: https://orcid.org/0000-0001-5097-0601)
Zhadanova Natalia V.
4th Student, Faculty of Dentistry, Penza State University, Russia, Penza (nata.zhadanova004@mail.ru; )
Karayan Arshavir V.
Post-Graduate Student, Department of Dentistry, Penza State University, Russia, Penza (stomatologfs@yandex.ru; )

Article link

Skvortsova E.N., Efremova A.V., Zyulkina L.A., Frolova K.E., Zhadanova N.V., Karayan A.V. The relationship of phys ological aging of the body with somatic diseases and pathology of the dento-facial system [Electronic resource] // Acta medica Eurasica. – 2026. – №1. P. 67-75. – URL: https://acta-medica-eurasica.ru/en/single/2026/1/7/. DOI: 10.47026/2413-4864-2026-1-67-75.