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Lutkova T.S., Speranskaya E.M., Andreeva N.P., Isaeva A.V., Lezhenina S.V.
The effectiveness of Secondary immunodeficiency therapy using bacteriophages: a clinical case
Keywords: secondary immunodeficiency, assessment of immune status, bacteriophages
The article is devoted to an urgent problem of practical medicine – secondary immunodeficiencies. In the practice of a primary care physician of any specialty, patients with secondary immunodeficiencies are much more common than those with primary immunodeficiency, but they are extremely rarely diagnosed. To date, there is no official diagnosis "secondary immunodeficiency", which explains why this condition is underdiagnosed and why there are no standardized approaches to its treatment. Secondary immunodeficiencies are known to develop in individuals whose immune systems were initially functioning normally and can manifest at any age. An important clinical sign of secondary immunodeficiency is an increased susceptibility to infectious diseases, caused by a reduction in the number and/or functional activity of immune system cells. Secondary immunodeficiencies most commonly manifest by respiratory diseases affecting the upper respiratory tract, formation of foci of chronic infection: nasopharyngitis, rhinosinusitis, otitis media, tonsillitis. Viral infections mainly inhibit the cellular component of the immune system, reducing the activity of CD4-lymphocytes, and cause an imbalance of cytokines. Frequent, sometimes unjustified prescribing of antibiotics leads to disruption of the intestinal microflora, which can worsen the course of secondary immunodeficiency. The article examines the main causes of secondary immunodeficiency, clinical classification and general approaches to patient management. The importance of a clinical and laboratory examination to clarify the affected link of immunity is shown. As part of the patient’s treatment, immunological parameters and the results of microbiological stool tests were analyzed. A clinical case of a patient with secondary immunodeficiency is described, demonstrating the effectiveness of therapy using bacteriophages.
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About authors
- Lutkova Tatiana S.
- Candidate of Medical Sciences, Associate Professor, Department of Polyclinic Therapy, Chuvash State University, Russia, Cheboksary (lts21@mail.ru; ORCID: https://orcid.org/0000-0003-2368-5084)
- Speranskaya Ekaterina M.
- Candidate of Medical Sciences, Associate Professor, Department of General and Clinical Morphology and Forensic Medicine, Chuvash State University, Russia, Cheboksary (ne28@bk.ru; ORCID: https://orcid.org/0000-0003-0946-3434)
- Andreeva Natalia P.
- Candidate of Medical Sciences, Associate Professor, Department of Healthcare Organization and Information Technologies, Chuvash State University, Russia, Cheboksary (Nataliutt@ya.ru; ORCID: https://orcid.org/0000-0002-1989-3334)
- Isaeva Alla V.
- Assistant Lecturer, Department of Polyclinic Therapy, Chuvash State University, Russia, Cheboksary (alushta111@mail.ru; )
- Lezhenina Svetlana V.
- Candidate of Medical Sciences, Associate Professor, Head of Department of Organization of Health Care and Information Technologies in Medicine, Chuvash State University, Russia, Cheboksary (svl-8@bk.ru; ORCID: https://orcid.org/0000-0002-1034-198X)
Article link
Lutkova T.S., Speranskaya E.M., Andreeva N.P., Isaeva A.V., Lezhenina S.V. The effectiveness of Secondary immunodeficiency therapy using bacteriophages: a clinical case [Electronic resource] // Acta medica Eurasica. – 2026. – №1. P. 44-55. – URL: https://acta-medica-eurasica.ru/en/single/2026/1/5/. DOI: 10.47026/2413-4864-2026-1-44-55.