UDC: 618.17:616-008.8:004.9
BBC: Р711.902.5+З891.02+Р215.5
Zakharova O.V., Eldyreva M.V., Gimaldinova N.E., Kopysheva T.N., Ivanova N.N., Petrov A.R., Diomidova V.N.
Internal diseases and reproductive health: associations of extragenital pathology with female infertility (a study based on analytical processing of data from clinical registries of the Chuvash Republic)
Keywords: internal diseases, comorbidity, extragenital pathology, female infertility, big data, intellectual analysis
Extragenital pathology is a significant factor that negatively affects the female reproductive function. Diseases of the endocrine system, anemia, and pathology of the urinary tract and digestive organs can disrupt key parts of the reproductive process: ovulation, blastocyst implantation and the onset and prolongation of pregnancy. The aim of the study was to study the spectrum and frequency of extragenital pathology in women of reproductive age with infertility in the context of various age categories based on the analysis of big data from clinical registries of the Chuvash Republic. Materials and methods. The analysis of incidence and structure of extragenital pathology in 4,469 reproductive-age patients with a diagnosis of infertility permanently residing in the Chuvash Republic for the period from 2023 to 2024 was carried out. The study cohort was stratified into five age groups: 21–25 years old (N1), 26-30 years old (N2), 31–35 years old (N3), 36–40 years old (N4) and 41–45 years old (N5). The diagnostic algorithm included a complex of clinical, laboratory, instrumental (including methods of radiation diagnostics) and, if indicated, histomorphological studies. Processing large data sets was performed using the "CS Analytics" analytical platform and specialized interactive dashboards were used for visualization and end-to-end analysis. Results. Of the total sample of patients (n = 220,440), the proportion of women of childbearing age with infertility was 2.03% (n = 4,469 people). The analysis of pathology structure in the general cohort of women showed the polymorphic nature of concomitant diseases, among which the most common were: pathology of the digestive system – 14.28%, diseases of the genitourinary system – 10.59%, respiratory diseases – 10.09%. The structure of the identified extragenital pathology in infertile patients varied depending on age. In group N1, diseases of the upper respiratory tract, nervous system, thyroid gland and iron deficiency anemia were most often diagnosed; in N2, disorders of the autonomic nervous system, inflammatory diseases of the respiratory tract, endemic goiter, myopia and anemia prevailed; in N3 and N4, the structure of comorbid pathology was comparable to group N2, but with a higher incidence of diseases otorhinolaryngological organs and peritoneal adhesions; in N5, the prevalence of endocrine and vascular pathology was noted. The analysis of age dynamics showed a statistically significant dependence of the frequency of diagnosed infertility on age: the peak incidence (32.69%) was recorded in the group of women aged 36–40 years, while the minimum rate (3.31%) was recorded in the group of young women aged 21–25 years. Conclusions. The study based on big data analysis revealed clear age-associated profiles of extragenital pathology in women of reproductive age with infertility. The data obtained substantiate the need to introduce a differentiated, multidisciplinary approach to examining women with infertility, as well as confirm high efficiency of digital analytical platforms for identifying complex clinical and epidemiological patterns.
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About authors
- Zakharova Oksana V.
- Candidate of Medical Sciences, Obstetrician-Gynaecologist at the Obstetric Department, University Clinical Hospital № 2, I.M. Sechenov First Moscow State Medical University (Sechenovskiy University), Russia, Moscow (zaharova260272@mail.ru; ORCID: https://orcid.org/https://orcid.org/0000-0003-3728-963X)
- Eldyreva Maria V.
- Candidate of Medical Sciences, Associate Professor of the Department of Normal and Topographic Anatomy with Operative Surgery, Chuvash State University, Russia, Cheboksary (konkova-masha@mail.ru; ORCID: https://orcid.org/0000-0003-2076-9477)
- Gimaldinova Natalia E.
- Candidate of Medical Sciences, Associate Professor, Department of General and Clinical Morphology and Forensic Medicine, Chuvash State University, Russia, Cheboksary (ngimaldinova@yandex.ru; ORCID: https://orcid.org/0000-0003-2475-3392)
- Kopysheva Tatiana N.
- Candidate of Physical and Mathematical Sciences, Associate Professor, Head of the Department of Mathematical and Hardware Support of Information Systems, Chuvash State University, Russia, Cheboksary (tn_pavlova@mail.ru; ORCID: https://orcid.org/0000-0003-3392-1431)
- Ivanova Nadezhda N.
- Candidate of Technical Sciences, Associate Professor, Department of Mathematical and Hardware Support of Information Systems, Chuvash State University, Russia, Cheboksary (niva_mail@mail.ru; ORCID: https://orcid.org/0000-0001-7130-8588)
- Petrov Aleksandr R.
- Head of the Training Center Group, Keysystems LLC, Russia, Cheboksary (petrick@keysystems.ru; )
- Diomidova Valentina N.
- Doctor of Medical Sciences, Professor, Head of the Department of Propaedeutics of Internal Diseases with a Course of Radiation Diagnostics, Chuvash State University; Head of the Department of Ultrasound Diagnostics, City Clinical Hospital № 1, Russia, Cheboksary (diomidovavn@rambler.ru; ORCID: https://orcid.org/0000-0002-3627-7971)
Article link
Zakharova O.V., Eldyreva M.V., Gimaldinova N.E., Kopysheva T.N., Ivanova N.N., Petrov A.R., Diomidova V.N. Internal diseases and reproductive health: associations of extragenital pathology with female infertility (a study based on analytical processing of data from clinical registries of the Chuvash Republic) [Electronic resource] // Acta medica Eurasica. – 2025. – №4. P. 28-39. – URL: https://acta-medica-eurasica.ru/en/single/2025/4/3/. DOI: 10.47026/2413-4864-2025-4-28-39.