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DOI: 10.47026/2413-4864-2025-3-55-67
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Matveeva M.D., Golubtsova N.N.

Features of proliferative activity of fibroblasts in the oral mucosa depending on body weight and age in humans are shown

Keywords: oral mucosa, fibroblasts, proliferation, aging, obesity, lack of nutrients

This article provides a review of the literature on proliferation of fibroblasts in the oral mucosa in the normal condition, in the group of the elderly and those with eating disorders. The purpose of the review is to summarize data from the world literature on structural and regeneration features of the oral mucosa and the relationship of these processes with age and nutritional status disorders. The oral mucosa is not only a gateway for penetration of microorganisms, but also a primary barrier. One of the main properties of the oral mucosa, regenerative one, is performed by fibroblasts, which are actively involved in the wound healing process. Fibroblasts have unusual regenerative abilities and can also take derivative into other types of cells when exposed to certain conditions, which indicates their high potential for multidirectional differentiation. Being the main components that create a new extracellular matrix of connective tissues, they support metabolism of the tissue being formed in case of damage. The proliferation phase during mucosal lesions healing begins a few days after injury, lasts up to three weeks and is characterized by high levels of secretion of growth factors. The processes of fibroblast proliferation are influenced by both physiological processes, such as aging, and pathological processes in the body such as obesity or malnutrition. The analysis of literary sources was carried out on the databases of electronic libraries of scientific publications: PubMed, Google Academy, Elibrary.ru. The search was performed using the following Key words: fibroblasts, proliferation, aging, obesity, lack of nutrients. To date, the regenerative potential of fibroblasts contained in the oral mucosa in the context of the problem of aging, as well as in cases of eating disorders, is an extensive topic for further scientific research with the prospect of practical application of the knowledge gained. The analysis of literary sources was carried out on the databases of electronic libraries of scientific publications: PubMed, Google Academy, Elibrary.ru. The search was conducted using the following Key words: fibroblasts, proliferation, aging, obesity, lack of nutrients. To date, the regenerative potential of fibroblasts of the oral mucosa in the aspect of aging and nutritional status disorders is an extensive topic for further scientific research with the prospect of practical application of the knowledge gained.

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About authors

Matveeva Mariya D.
Senior Lecturer, Department of Orthopedic Dentistry and Orthodontics, Chuvash State University, Russia, Cheboksary (masha_matveyeva@inbox.ru; ORCID: https://orcid.org/0009-0006-6516-4585)
Golubtsova Natalya N.
Doctor of Biological Sciences, Associate Professor, Head of the Department of General and Clinical Morphology and Forensic Medicine, Chuvash State University, Russia, Cheboksary (golubnata@list.ru; ORCID: https://orcid.org/0000-0002-5436-1333)

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Matveeva M.D., Golubtsova N.N. Features of proliferative activity of fibroblasts in the oral mucosa depending on body weight and age in humans are shown [Electronic resource] // Acta medica Eurasica. – 2025. – №3. P. 55-67. – URL: https://acta-medica-eurasica.ru/en/single/2025/3/7/. DOI: 10.47026/2413-4864-2025-3-55-67.

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