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Denisova T.G., Vasilievа E.N., Gruzinova E.N., Denisova E.A., Romanova L.P.
Features of gynecological history and vitamin D sufficiency in women with infertility
Keywords: infertility, gynecological morbidity, vitamin D deficiency, prevention
The aim of the study was to analyze the gynecological history and to determine the level of vitamin D in patients with infertility. The study involved 48 women with the diagnosis: "infertility" and 30 pregnant women of 7–10 weeks of gestation. In patients, the content of vitamin D was examined by the concentration of 25 (OH)D in blood serum by the enzyme immunoassay (BIOMEDICAGRUPPE kits (Germany)). Vitamin D sufficiency was assessed according to the clinical recommendations of the Russian Association of Endocrinologists (2015): normal level – 30–35 ng/ml, insufficiency – 10–20 ng/ml, deficit – 10 ng/ml or lower. According to the results of the study, it was revealed that the level of somatic pathology in patients with infertility is 2 times higher than in pregnant women, and the level of gynecological morbidity and obstetric complications is higher than in women of the control group: diseases of the uterus and uterine adnexa are 2.4 times more often, uterine fibroids are 3.0 times more often, endometriosis is 4.6 more often, missed abortions are 3.8 more often, spontaneous abortions are 2.2 times more often, abortions are 2.7 times more often. At the same time, patients with infertility were found to have vitamin D deficiency, while in pregnant patients vitamin D levels were within the limits of the physiological norm. Thus, it is possible that vitamin D sufficiency affects the reproductive system functioning, the level of reproductive losses, gynecological morbidity, including infertility, respectively, vitamin D can be used in combination in the treatment and prevention of infertility.
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About authors
- Denisova Tamara G.
- Doctor of Medical Sciences, Professor, Department of Obstetrics and Gynecology, Chuvash State University, Russia, Cheboksary (tomadenisova@rambler.ru; ORCID: https://orcid.org/0000-0002-0517-2632)
- Vasilieva Elvira N.
- Candidate of Medical Sciences, Associate Professor of the Department of Obstetrics and Gynecology, Chuvash State University, Russia, Cheboksary (elnikvas@mail.ru; )
- Gruzinova Elena N.
- Candidate of Medical Sciences, Associate Professor of the Department of Obstetrics and Gynecology, Chuvash State University, Russia, Cheboksary (elena-gruzinova00@rambler.ru; )
- Denisova Elena A.
- Candidate of Medical Sciences, Associate Professor, Department of Obstetrics and Gynecology, Chuvash State University, Russia, Cheboksary (gubanova.elena@gmail.com; ORCID: https://orcid.org/0000-0002-5054-3826)
- Romanova Lubov P.
- Candidate of Medical Sciences, Associate Professor of the Department of Dermatovenerology with a course of Hygiene, Chuvash State University, Russia, Cheboksary (Samung2008@yandex.ru; )
Article link
Denisova T.G., Vasilievа E.N., Gruzinova E.N., Denisova E.A., Romanova L.P. Features of gynecological history and vitamin D sufficiency in women with infertility [Electronic resource] // Acta medica Eurasica. – 2020. – №2. P. 1-7. – URL: https://acta-medica-eurasica.ru/en/single/2020/2/1/.