UDC: [616.329+618.1]-006.6-073.75
BBC: Р569.433-436+Р569.71-436
Diomidova V., Safonova M., Dmitrieva A., Vinogradova V.
Radiation diagnosis of primary multiple malignancies involving the gastrointestinal tract and female reproductive organs
Keywords: radiation diagnosis, primary multiple neoplasms, stomach, cancer, female reproductive organs
The purpose of the research is to study the informative value of diagnostic radiology in primary multiple malignant neoplasms (PMMNs) involving the gastrointestinal tract and female reproductive organs. The relevance is due to annual increase in the number of newly diagnosed cancer patients, including polyneoplasias. Diagnostic radiology methods – ultrasound, X-ray, computer and magnetic resonance imaging – were used. Statistical analysis was carried out using the methods of medical statistics (significant differences – p ≤ 0,05). Involvement of the gastrointestinal organs among patients with multiple primary malignant neoplasms was diagnosed in 385 patients (mean age 55,2±2,9 years).There were fewer women (173 women, 44,9%) than men. Simultaneous malignant neoplasms (MNs) of the gastrointestinal tract were diagnosed in 96 patients (24.94%), metachronous – in 289 (75,06%). Combination of metachronous malignant tumors of the gastrointestinal tract with endometrium was revealed in 14 patients (4,8%), with breast cancer – in 25 patients (8,6%), with myometrium – in 9 patients (3,1%), with cervix and ovary – 3 cases (1,04%) with each. Synchronous PMMNs with involvement of the gastrointestinal tract and female reproductive organs included: esophagus – endometrium – 1 case (1,04%); stomach – mammary gland, stomach – uterine body – 1 case for each (1,04%); colon – mammary gland and colon – ovaries – 4 cases each (4,2%); colon – cervix and colon – endometrium – 1 case each (1,04%). The informative value of complex diagnostic radiology was: sensitivity – 90,28%, specificity –91,43%, accuracy – 90,85%. To detect polyneoplasia, it is necessary to use all diagnostic radiology technologies available in the algorithm of patients’ examination both at the stage of screening and at the stage of primary and differential diagnosis of primary multiple and metastatic tumors of the digestive organs and all other systems.
References
- Akberov R.F., Zyyatdinov K.Sh., Mikhailov M.K., Yakhin M.M., Nurgaliev R.G., Sakhapova L.R., Safiullina L.R., Diomidova V.N., Utkel’baev R.I. Kompleksnaya kliniko-luchevaya diagnostika zabolevanii, funktsional’nykh narushenii, porokov razvitiya i opukholevykh porazhenii pishchevoda, zheludka i piloroduodenal’noi zony [Complex clinical and radiation diagnosis of diseases, functional disorders, malformations and tumor lesions of the esophagus, stomach and pyloroduodenal zone]. Naberezhnye Chelny, 2010, 413 p.
- Diomidova V.N. Vizual’naya kharakteristika neizmenennogo i operirovannogo zheludka pri ul’trazvukovom issledovanii [Visual Characteristic of Unaltered and Operated Stomach with the Help of Ultrasound Research]. Meditsinskaya vizualizatsiya, 2015, no. 4, pp. 46–55.
- Diomidova V.N. Ul’trazvukovaya angiografiya i otsenka opukholevoi invazii sosudov pri rake zheludka [Ultrasound angiography and evaluation of tumor invasion of vessels in gastric cancer]. Vestnik Chuvashskogo universiteta, 2007, no. 2, pp. 72–78.
- Diomidova V.N. Ul’trasonografiya v diagnostike opukholei zheludka: avtoref. dis. … kand. med. nauk [Ultrasonography in the diagnosis of gastric tumors]. Kazan, 1999.
- Diomidova V.N., Zakharova O.V., Petrova O.V. Elastografiya sdvigovoi volnoi v otsenke endometriya i miometriya u zdorovykh zhenshchin reproduktivnogo vozrasta [Endometrium and Myometrium Shear Wave Elastography in Healthy Women of Reproductive Age]. Ul’trazvukovaya i funktsional’naya diagnostika, 2015, no. 5, pp. 51–56.
- Kaprin A.D., Starinskii V.V., Petrova G.V., eds. Zlokachestvennye novoobrazovaniya v Rossii v 2017 godu (zabolevaemost’ i smertnost’) [Malignant neoplasm in Russia in the year 2017 (morbidity and mortality]. Moscow, 2018, 250 p.
- Ignat’ev A.I., Ukhanov A.P., Mergenov M.M., Malyushenkov I.V. Pervichno-mnozhestvennyi sinkhronnyi rak zheludka, shchitovidnoi i molochnoi zhelez [Primary multiple synchronous cancer of the stomach, thyroid and breast]. Khirurgiya, 2007, no. 12, p. 49.
- Kutalia P.Z., Sel’chuk V.Yu., Payanidi Yu.G., Zhordania K.I., Shelepova V.M., Zakharova T.I. Zlokachestvennye novoobrazovaniya yaichnikov i polineoplazii: klinika, diagnostika, zakonomernosti razvitiya, prognoz [Ovarian malignancies and polyneoplasias: clinical presentation, diagnosis, mechanisms of development, prognosis]. Opukholi zhenskoi reproduktivnoi sistemy, 2011, no. 1, pp. 80–86.
- Popova T.N., Fedorov V.E., Kharitonov B.S. Pervichno-mnozhestvennye sinkhronnye zlokachestvennye novoobrazovaniya pishevaritel’noi sistemy [Multifocal synchronous malignant growths of digestive system]. Meditsinskii al’manakh, 2011, no. 5(18).
- Rukhadze G.O., Skopopad V.Yu., Berdov B.A. Risk razvitiya metakhronnykh zlokachestvennykh opukholei posle khirurgicheskogo i kombinirovannogo (s predoperatsionnoi i intraoperatsionnoi luchevoi terapiei) lecheniya bol’nykh rakom zheludka [Risk of developing metachronic carcinomas in gastriccancer patients treated with surgery alone and in combination with preoperative and intraoperativeradiation therapy]. Sibirskii onkologicheskii zhurnal, 2013, no. 5(59), pp. 17–19.
- Safonova M.A., Diomidova V.N., Zakharova O.V., Ionov A.M., Siordiya A.A. Porazhenie zhenskikh reproduktivnykh organov v strukture pervichno-mnozhestvennykh zlokachestvennykh novoobrazovanii [Affection of female reproductive organs in the structure of multiple primary malignant neoplasms]. Voprosy ginekologii, akusherstva i perinatologii, 2016, vol. 15, no. 3, pp. 48–53.
- Sviridov A.A. Rak zheludka v aspekte sinkhronnykh pervichno-mnozhestvennykh zlokachestvennykh novoobrazovanii: avtoref. dis. … kand. med. nauk [Stomach cancer in the aspect of synchronous primary multiple malignancies. Diss. Abstract]. Moscow, 2003.
- Sel’chuk V.Yu. Pervichno-mnozhestvennye zlokachestvennye opukholi (klinika, lechenie i zakonomernosti razvitiya): dis. … d-ra med. nauk [Primary-multiple malignant tumors (clinic, treatment and development patterns)]. Moscow, 1994, p. 68.
- Chissov V.I., Starinskii V.V., Petrova G.V., eds. Sostoyanie onkologicheskoi pomoshchi naseleniyu Rossii v 2011 godu [State of Oncology aid rendered to population of Russia in 2011 year]. Moscow, 2012, 240 p.
- Ukhanov A.P., Mergenov M.M., Ignat’ev A.I., Malyushenko I.V. Rak zheludka pri pervichno-mnozhestvennykh zlokachestvennykh opukholyakh u bol’nykh starshikh vozrastnykh grupp [Stomach cancer in primary multiple malignant tumors in patients of older age groups]. Rossiiskii onkologicheskii zhurnal, 2007, no. 2, pp. 40–43.
- Chissov V.I., Trakhtenberg A.Kh., Frank G.A. Razvitie ucheniya o pervichnoi mnozhestvennosti zlokachestvennykh opukholei [Development of the doctrine of a plurality of primary malignant tumors]. In Chissov B.I., Trakhtenberg A.Kh., eds. Pervichno-mnozhestvennye zlokachestvennye opukholi [Primary-multiple malignant tumors]. Moscow, Meditsina Publ., 2000, pp. 7–29.
- Chakrapan E., Weerapat S. Metachronous Second Primary Colorectal Cancer in Patients with Gastric Cancer: Two Cases Report and Literature Review. The Thai J. Surg., 2011, vol. 32, pp. 35–40.
- Lee H., Lee V., Kim S. et al. Microsatellite instability in synchronous gastric carcinomas. J. Cancer., 2001, vol. 91, pp. 619–624.
- Martini N., Melamed M.R. Multiple primary lung cancers. Thorac. Cardiovasc. Surg., 1975, vol. 70, pp. 606–612.
About authors
- Diomidova Valentina N.
- Doctor of Medical Sciences, Professor, Head of the Department of Propaedeutics of Internal Diseases with a Course of Radiation Diagnostics, Chuvash State University; Head of the Department of Ultrasound Diagnostics, City Clinical Hospital № 1, Russia, Cheboksary (diomidovavn@rambler.ru; ORCID: https://orcid.org/0000-0002-3627-7971)
- Safonova Marina Anatolievna
- Republican Clinical Oncology Dispensary radiology unit head; obstetrics and gynecology department graduate student, Chuvash State University, Russia, Cheboksary (safmaran@yandex.ru; )
- Vinogradova Valentina Sergeevna
- obstetrics and gynecology department graduate student, Chuvash State University, Russia, Cheboksary )
- Dmitrieva Anastasia N.
- Post-Graduate Student, Department of Propaedeutics of Internal Diseases with a Course of Radiation Diagnostics, Chuvash State University; Radiologist, Republican Clinical Oncology Dispensary, Russia, Cheboksary (dmitrieva.rabota@mail.ru; )
Article link
Diomidova V., Safonova M., Dmitrieva A., Vinogradova V. Radiation diagnosis of primary multiple malignancies involving the gastrointestinal tract and female reproductive organs [Electronic resource] // Acta medica Eurasica. – 2019. – №1. P. 18-24. – URL: https://acta-medica-eurasica.ru/en/single/2019/1/3/.