Clinical and Laboratory Characteristics of Glomerulonephritises with Nephrotic Syndrome in Adults

DOI: 10.47026/2413-4864-2024-2-10-18

UDC: 616.61
BBC: 54.14

Kudryashov S.I.

Clinical and Laboratory Characteristics of Glomerulonephritises with Nephrotic Syndrome in Adults

Keywords: primary glomerulonephritises, nephrotic syndrome, refractory nephrotic syndrome, complications of nephrotic syndrome

Glomerulonephritises, manifested by nephrotic syndrome, are common in both children and adults. Clinical and laboratory manifestations of glomerulonephritises with nephrotic syndrome in adults have been poorly studied due to their lower prevalence and difficulty of selecting representative cohorts of subjects. The aim of the study was to study clinical and laboratory features of glomerulonephritises with nephrotic syndrome in adults. Material and methods. A retrospective study of medical histories and outpatient records of patients with primary glomerulonephritises who underwent examination and treatment in the nephrological department and/or nephrological office at the consultative and diagnostic center of the BI "Republican Clinical Hospital" under the Health Ministry of Chuvashia in 2005-2014 was conducted. At this, from the total number of patients with glomerulonephritises, patients with primary glomerulonephritises with nephrotic syndrome belonging to the Chuvash ethnic population were selected for the study group. Clinical and demographic, laboratory and instrumental indicators of the subjects were entered into Excel environment for subsequent statistical data processing in Statistica 10.0 program. Research results. When analyzing the age structure of the onset of glomerulonephritises with nephrotic syndrome, it was found that the disease manifested and was diagnosed most often in the age range of 40-49 years (23% of the subjects), the median age of onset was 41 years. There were 68% of male patients in the cohort of subjects. Membranous nephropathy was found in 39% of patients, focal segmental glomerulosclerosis – in 32%, and the disease with minimal changes – in 23%. Refractory nephrotic syndrome occurs in 31% of patients, arterial hypertension – in 35%, coronary heart disease – in 6.3%, infectious complications – in 8.5%, thromboses or vascular thromboembolism – in 6.7%. Correlations of clinical and laboratory parameters were found, in particular, the rate of nephrotic syndrome recurrence correlated with daily proteinuria (r_s = 0.47), serum creatinine level (r_s = 0.44), estimated glomerular filtration rate (r_s = –0.49). Conclusions. The characteristics was given to clinical and laboratory manifestations and the pathomorphological structure of the group of glomerulonephritises with nephrotic syndrome in the Chuvash population, which generally do not differ from those in the pan-European population.

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About authors

Kudryashov Sergei I.: Candidate of Medical Sciences, Associate Professor, Department of Internal Diseases, Chuvash State University, Russia, Cheboksary (medicpro21@mail.ru; ORCID: https://orcid.org/0000-0003-2277-9425)

Article link

Kudryashov S.I. Clinical and Laboratory Characteristics of Glomerulonephritises with Nephrotic Syndrome in Adults [Electronic resource] // Acta medica Eurasica. – 2024. – №2. P. 10-18. – URL: https://acta-medica-eurasica.ru/en/single/2024/2/2/. DOI: 10.47026/2413-4864-2024-2-10-18.

Single article

Kudryashov S.I.