Single article

DOI: 10.47026/2413-4864-2021-4-60-72

Opalinskaya I.V., Danilova G.V., Isaeva N.Yu., Petrova E.S., Busalaeva E.I., Vasilyeva N.P., Sergeev A.V.

Primary Amyloidosis Involvong the Heart: Clinical Observation

Keywords: cardiac amyloidosis, amyloid cardiomyopathy, heart failure, Bortezomib

Primary amyloidosis is a disease with a complex and not fully understood pathogenesis, which is characterized by a wide range of clinical manifestations. Light chain amyloidosis is the most common form of systemic amyloidosis. At this, the heart is the dominant target organ in systemic amyloidosis. Cardiac amyloidosis (amyloid cardiomyopathy) is most often manifested by diastolic heart failure resulting from restrictive cardiomyopathy. Therapy of amyloid cardiopathy includes optimal treatment of heart failure and chemotherapy. To reduce the symptoms of heart failure, diuretics are the main means, since other pathogenetic agents cannot be used due to hypotension and a possible decrease in cardiac output. With the introduction of new medicinal products into clinical practice, such as the proteosome inhibitor Bortezomib, the prognosis for patients has improved. However, amyloidosis remains a difficult disease to diagnose and treat.

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About authors

Opalinskaya Irina V.
Candidate of Medical Sciences, Associate Professor, Department of Faculty and Hospital Therapy, Chuvash State University, Russia, Cheboksary (opalinskaya_irina@mail.ru; ORCID: https://orcid.org/0000-0002-5760-269X)
Danilova Galina V.
Resident of Department of Faculty and Hospital Therapy, Chuvash State University, Russia, Cheboksary (galiamyasnikova@yandex.ru; ORCID: https://orcid.org/0000-0003-4124-1241)
Isaeva Natalya Yu.
Resident of Department of Faculty and Hospital Therapy, Chuvash State University, Russia, Cheboksary (natalya231096@mail.ru; ORCID: https://orcid.org/0000-0002-2279-9517)
Petrova Ekaterina S.
Resident of Department of Faculty and Hospital the Therapy, Chuvash State University, Russia, Cheboksary (ekaterina1996.96@mail.ru; ORCID: https://orcid.org/0000-0002-9515-0639)
Busalaeva Elena I.
Candidate of Medical Sciences, Associate Professor, Department of Internal and Family Medicine, The Institute of Postgraduate Medical Education; Associate Professor of Faculty and Hospital Therapy Department, Chuvash State University, Russia, Cheboksary (busa-elena@yandex.ru; ORCID: https://orcid.org/0000-0001-7313-0365)
Vasilieva Nina P.
Candidate of Medical Sciences, Associate Professor, Department of Faculty and Hospital Therapy, Chuvash State University, Russia, Cheboksary (ninajur@yandex.ru; ORCID: https://orcid.org/0000-0002-0183-9436)
Sergeev Alexander V.
Candidate of Medical Sciences, Deputy Chief of Medical Affairs, Pathologist, Republican Bureau of Forensic Medical Examination of the Ministry of Health of Chuvashia; Associate Professor, Department of General and Clinical Morphology and Forensic Medicine, Chuvash State University, Russia, Cheboksary (sergeevav@rbsme.ru; ORCID: https://orcid.org/0000-0002-8230-8927)

Article link

Opalinskaya I.V., Danilova G.V., Isaeva N.Yu., Petrova E.S., Busalaeva E.I., Vasilyeva N.P., Sergeev A.V. Primary Amyloidosis Involvong the Heart: Clinical Observation [Electronic resource] // Acta medica Eurasica. – 2021. – №4. P. 60-72. – URL: http://acta-medica-eurasica.ru/en/single/2021/4/7/. DOI: 10.47026/2413-4864-2021-4-60-72.