Single article

Kostrova O., Kotelkina A., Merkulova L., Stomenskaya I., Struchko G., Timofeeva N., Bubnova N.

Changes in the Content of Biogenic Amines and Their Ratio in Adrenal Glands and the Thymus Under Water-Immobilization Stress

Keywords: thymus, adrenal glands, biogenic amines, stress, histamine, serotonin, catecholamines, luminescent granular cells

The thymus and adrenal glands of 40 female rats were studied using luminescent histochemical methods. The animals were divided into two groups: intact animals and rats subjected to water-immobilization stress lasting one hour daily during 10 days. Animals were withdrawn from the experiment in 1, 2 and 3 months after the end of exposure. It is established that water-immobilization stress changes the mass of organs, the level of biogenic amines in the thymus and adrenal glands, the ratio (CT+GST)/KA and the number of luminescent granular cells. Both in the thymus, and in the adrenal glands, all changes are of wavy and opposite character and depend on the phase of the stress reaction. The alarm phase was registered by us in rats in 1 month after the end of exposure, in 2 months later – the phase of resistance. In 3 months the phase of exhaustion forms.

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About authors

Kostrova Olga Yu.
Candidate of Medical Sciences, Assistant Professor, Head of Department of the Instrumental Diagnostics with a Course of Phthisiology, Chuvash State University, Russia, Cheboksary (evkbiz@yandex.ru)
Kotelkina Anastasia
Assistant Lecturer of Normal and Topographic Anatomy Department, Chuvash State University, Russia, Cheboksary (ds6426@chebnet.com)
Merkulova Larisa M.
Doctor of Medical Sciences, Professor of Normal and Topographic Anatomy Department, Chuvash State University, Russia, Cheboksary (merkulova192@mail.ru)
Stomenskaya Irina S.
Candidate of Medical Sciences, Assistant Professor, Department of the Instrumental Diagnostics with a Course of Phthisiology, Chuvash State University, Russia, Cheboksary (irina.stomenskaja@gmail.com)
Struchko Gleb Yu.
Doctor of Medical Sciences, Professor, Head of Normal and Topographic Anatomy Department, Chuvash State University, Russia, Cheboksary (glebstr@mail.ru)
Timofeeva Natalya Yu.
Assistant Lecturer, Department of Instrumental Diagnostics Department with a Course of Phthisiology, Chuvash State University, Russia, Cheboksary (bla11blabla@yandex.ru)
Bubnova Natalia
Assistant Lecturer, Department of Instrumental Diagnostics Department with a Course of Phthisiology, Chuvash State University, The Republic of Uzbekistan, Cheboksary (natalia210485@yandex.ru)

Article link

Kostrova O., Kotelkina A., Merkulova L., Stomenskaya I., Struchko G., Timofeeva N., Bubnova N. Changes in the Content of Biogenic Amines and Their Ratio in Adrenal Glands and the Thymus Under Water-Immobilization Stress [Electronic resource] // Acta medica Eurasica. – 2019. – №3. P. 53-60. – URL: http://acta-medica-eurasica.ru/en/single/2019/3/7/.