Single article

Nalimova N., Efeykina N.

The Content of Biologically Active Substances in Hypericum Perforatum L. and the Pharmacotherapeutic Effect of Drugs Based on it (Review)

Keywords: Pharmacopoeia plant, active substances, hypericin, flavonoids, hyperforin, sterols, pharmacological activity, pharmacotherapeutic range

The aim of this work was to present the results of generalizing literature data on the chemical composition, pharmacotherapeutic effect of biologically active substances of the plant Hypericum perforatum L. and the spectrum of phytopreparations use in the clinical practice. The chemical composition of St. John's wort (Hyperici herba) is studied quite fully within the Eurasian natural habitat of the species, more than 80 components were isolated. The main biologically active compounds of raw materials are anthracene derivatives (hypericin), flavonoids (rutin, quercetin, hyperoside), phenylpropanoids (chlorogenic acid) and phloroglucinol hyperforin, which have a wide range of pharmacological actions and characterizing a species-specificity of the plant Hypericum L.. Photosensitizing hypericins and hormone-like sterols determine side effects of St. John's wort preparations. The results of pharmacognostic and pharmacological studies determine feasibility of clinical trials using St. John's wort preparations and their use in a large therapeutic range in complex treatment of diseases. St. John's wort herb is a promising source of raw materials for antibacterial, antiviral, anti-inflammatory, astringent, diuretic, antidepressant, antioxidant, anticarcinogenic, immunotropic and adaptogenic agents.

References

  1. Azarova O.V., Galaktionova L.P. Flavonoidy: mekhanizm protivovospalitel’nogo deistviya [Flavonoids: a mechanism of anti-inflammatory action]. Khimiya rastititel’nogo syr’ya [Chemistry of Plant Raw Material], 2012, no. 4, pp. 61–78.
  2. Aizeman B.E., Derbentsova N.A. Antimikrobnye preparaty iz zveroboya [Antimicrobial preparations from Hypericum]. Kiev, Naukova dumka Publ., 1976, 156 p.
  3. Alyukina L.S. Soderzhanie flavonoidov u nekotorykh vidov zveroboya [The content of flavonoids in some species of Hypericum]. Biokhimiya obmena veshchestv i produktivnost’ rastenii [Biochemistry of metabolism and plant productivity]. Alma-Ata, Nauka Publ., 1970, pp. 161–169.
  4. Vasil’chenko E.A., Vasil’eva L.N., Komissarenko N.F. Anal’geziruyushchee deistvie flavonoidov Rhododendron luteum Sweet, Hypericum perforatum L., Lespedeza bicolor Turcz. i L. hedysaroides (Pall.) Kitag [The analgesic effect of flavonoids Rhododendron luteum Sweet, Hypericum perforatum L., Lespedeza bicolor Turcz.]. Rastititel’nye resursy [Plant Resources and Environment], 1986, vol. 22, iss. 1, pp. 12–21.
  5. Bayandina I.I. Izmenchivost’ soderzhaniya biologicheski aktivnykh veshchestv u introduktsionnykh populyatsii zveroboya prodyryavlennogo v sravnenii s sortom Zolotodolinskim [Variability of the content of biologically active substances in the introduction populations of Hypericum perforatum in comparison with the variety Zolotodolinsky]. Sibirskii ekologicheskii zhurnal [Siberian Journal of Ecology], 1999, no. 3, p. 104.
  6. Blinova K.F., Borisova N.A., Gortinskii G.B., Grushvitskii I.V. Botaniko-farmakognosticheskii slovar’: spravochnoe posobie [Botanical and pharmacognostic dictionary: reference guide]. Moscow, Vysshaya shkola Publ., 1990, 272 p.
  7. Volosovets P.S., Reznik S.R. Novoimanin – stimulyator immunogeneza [Novoimanin – a stimulator of immunogenesis]. Fitontsidy [Volatile]. Kiev, Naukova dumka Publ., 1972, pp. 203–205.
  8. Drobizhev M.Yu., Syrkin A.L., Poltavskaya M.G., Pecherskaya B. Gelarium Giperikum pri lechenii depressii v obshchesomaticheskoi seti [Gelarium Hypericum in the treatment of depression in the somatic network]. Psikhiatriya i psikhofarmakoterapiya [Psychiatry and Clinical Psychopharmacology], 2002, vol. 4, no. 5, pp. 198–199.
  9. Gerasimov A. I. Ob effektivnosti primeneniya novoimanina pri ingalyatsii v kompleksnom lechenii tuberkuleza legkikh i tuberkuleznogo laringita [On the effectiveness of the use of novaimanin for inhalation in the complex treatment of pulmonary tuberculosis and tuberculous laryngitis]. Fitontsidy [Volatile]. Kiev, Naukova dumka Publ., 1972, pp. 225–226.
  10. Gordienko A.D. Gepatoprotektornyi mekhanizm deistviya flavonoidov [Hepatoprotective mechanism of action of flavonoids]. Farmatsiya [Pharmacy], 1990, no. 2, pp. 75–78.
  11. Gosudarstvennaya Farmakopeya Rossiiskoi Federatsii: Ministerstvo zdravookhraneniya RF: v 4 t. 14-e izd. [State Pharmacopoeia of the Russian Federation: Ministry of Health of the Russian Federation. 4 vols. 14th]. Moscow, 2018, vol, 4, pp. 5188–7016. Available at: http://femb.ru/femb/ pharmacopea.php (Accessed 1 August 2019)
  12. Gosudarstvennaya farmakopeya SSSR. Obshchie metody analiza. Lekarstvennoe rastitel’noe syr’e: Ministerstvo zdravookhraneniya SSSR. Vyp. 2. 11-e izd [State Pharmacopoeia of the USSR. General methods of analysis. Medicinal plant raw materials: Ministry of Health of the USSR. Issue 2. 11th]. Moscow, Medicine Publ., 1990, 400 p.
  13. Gritsai A.V., Tomakh N.V. Primenenie ekstrakta zveroboya v kompleksnoi terapii psikhoemotsional’nykh rasstroistv u patsientov s gipertonicheskoi bolezn’yu [The use of Hypericum extract in the complex treatment of psychoemotional disorders in patients with hypertension]. Praktikuyushchemu nevrologu [To Practicing Neurologist], 2012, no. 2(48), pp. 202–204.
  14. Gromova N.M. Farmakognosticheskoe izuchenie evropeiskikh vidov zveroboya Hypericum perforatum L. i H. quadrangulum L: avtoref. dis. … kand. farmats. nauk [Pharmacognostic study of European Hypericum species Hypericum perforatum L. and H. quadrangulum L. Abstract of PhD thesis]. Moscow, 1952, 14 p.
  15. Gubanov I.A., Krylova I.A., Tikhonova V.L. Dikorastushchie poleznye rasteniya SSSR [Wild useful plants of the USSR]. Moscow, Mysl Publ., 1976, 360 p.
  16. Evstafeeva T.A. Immunofarmakologicheskaya kharakteristika zveroboya prodyryavlennogo: avtoref. dis. …kand. biol. nauk [Immunopharmacological characteristics of Hypericum perforatum. Abstract of PhD thesis]. Ufa, 1994, 26 p.
  17. Zhebeleva T.I. Nekotorye dannye biokhimicheskogo analiza zveroboev Predural’ya [Immunopharmacological characteristics of Hypericum perforatum]. Uchenye zapiski Permskogo universiteta [Scientific papers of the Perm University], 1976, iss. 6, no. 336, pp. 114–115.
  18. Zhebeleva T.I., Teslov S.V., Glumov G.A. Sravnitel’nyi lyuminestsentno-khromatograficheskii analiz nekotorykh vidov zveroboya yuzhnogo Predural’ya [Comparative luminescence-chromatographic analysis of some species of Hypericum in the southern Urals]. Nauchnye trudy Permskogo meditsinskogo institute [Scientific papers of the Perm Medical Institute], 1975, iss. 8, pp. 89–94.
  19. Zaitseva M.M. Vliyanie zveroboya obyknovennogo na ZhKT [The effect of Hypericum perforatum on the digestive tract]. Zdravookhranenie Belorussii [Health of Belarus]. 1966, no. 5, pp. 23–25.
  20. Zemtsova G.N., Shvarts V.Ya. Effektivnost’ fitoterapii v kompleksnom lechenii bol’nykh postdizenteriinym kolitom [The effectiveness of herbal medicine in the complex treatment of patients with post-dysenteric colitis]. 2-ya respublikanskaya konferentsiya po meditsinskoi botanike [Proc. of 2nd Republican Conf. on Medical Botany]. Kiev, 1988, pp. 353–354.
  21. Zimina L.N. Farmakognosticheskoe issledovanie po obosnovaniyu sozdaniya antidepressantnykh preparatov na osnove travy zveroboya: avtoref. dis. … kand. farmats. nauk [Pharmacognostic study to justify the creation of antidepressant drugs based on hypericum herb. Abstract of PhD thesis]. Samara, 2011, 24 p.
  22. Zolotnitskaya S.Ya., Akopyan G.O. O soderzhanii vitamina E v nekotorykh rasteniyakh iz flory Armenii [On the content of vitamin E in some plants from the flora of Armenia]. Byulleten’ Botanicheskogo sada AN ArmSSR [Bulletin of the Botanical Garden of AN ArmSSR.], 1954, no. 14, pp. 75–92.
  23. Shakirova K.K., Bandyukova V.A., Khalmatov Kh.Kh. Issledovanie flavonoidov nekotorykh vidov zveroboya [The study of flavonoids of some species of hypericum]. Materialy yubileinoi respublikanskoi nauchnoi konferentsii farmatsevtov [Proc. of the Anniversary Republican Conf. of Pharmacists]. Tashkent, 1972, pp. 40–41.
  24. Kabiev O.K., Balmukhanov S.B. Prirodnye fenoly perspektivnyi klass protivoopukholevykh i radiopotentsiiruyushchikh soedinenii [Natural phenols are a promising class of antitumor and radiopotentiating compounds]. Moscow, Medicine Publ., 1975, 189 p.
  25. Kirilyuk Zh.I. Eksperimental’noe obosnovanie primeneniya preparatov zveroboya i kalankhoe pri lechenii infitsirovannykh ran [An experimental justification for the use of Hypericum and Kalanchoe preparations in the treatment of infected wounds]. Vestnik khirurgii [Bulletin of Kyrgyzstan], 1978, no. 4, pp. 126–130.
  26. Kitanov G.M. Fitokhimicheskoe izuchenie i analiz vidov Hypericum L., proizrastayushchikh v Bolgarii [Phytochemical study and analysis of Hypericum L. species growing in Bulgaria]. Rastitel’nye resursy [Plant Resources and Environment]. 1988, vol. 24, iss. 1, pp. 114–121.
  27. Kukenov M.K., Mikhailova V.P. O flavonoidnosti nekotorykh rastenii flory Kazakhstana [About the flavonoid of some plants of the Kazakhstan flora]. Vestnik AN Kazakhskoi SSR [Bulletin of the Academy of Sciences of the Kazakh SSR], 1974, no. 12, pp. 31–36.
  28. Kurkin V.A., Pravdivtseva O.E. Flavonoidy nadzemnoi chasti Hypericum perforatum [Flavonoids of the aboveground part of Hypericum perforatum]. Khimiya prirodnykh soedinenii [Chemistry of Natural Compounds]. 2007, no. 5, pp. 512–513.
  29. Kucherov E.V., Karimova S.G. Soderzhanie biologicheski aktivnykh veshchestv v rasteniyakh flory Bashkirskogo Predural’ya [The content of biologically active substances in plants of the flora of the Bashkir Urals]. Dikorastushchie i introdutsiruemye poleznye rasteniya v Bashkirii [Wild and introduced useful plants in Bashkiria]. Ufa, 1974, iss. 4, pp. 61–88.
  30. Lebedev A.V. Sravnitel’noe farmakognosticheskoe izuchenie ofitsial’nykh vidov roda zveroboi: avtoref. dis. … kand. farmats. nauk [Comparative pharmacognostic study of official species of the genus Hypericum. Abstract of PhD thesis]. Perm, 2000, 22 p.
  31. Belodubrovskaya G.A., Blinova K.F., Vandyshev V.V. Lekarstvennoe rastitel’noe syr’e. Farmakognoziya [Medicinal plant raw material. Pharmacognosy]. St. Petersburg, SpetsLit Publ., 2004, 765 p.
  32. Klyueva M.A., Babayana A Lekarstvennye preparaty, razreshennye k primeneniyu v SSSR [Drugs permitted for use in the USSR]. Moscow, Medicine Publ., 1979, 352 p.
  33. Samylina I.A., Severtsev V.A., Sorokina A.A., Ermakova V.A. Lekarstvennye rasteniya gosudarstvennoi farmakopei. Farmakognoziya. Ch. 2 [Medicinal plants of the State Pharmacopoeia. Pharmacognosy. Part 2]. Moscow, ANMI Publ., 2003, 534 p.
  34. Kazarinova N.V., Lomonosova M.N., Tril’ B.M. Lekarstvennye rasteniya Sibiri dlya lecheniya serdechno-sosudistykh zabolevanii [Medicinal plants of Siberia for the treatment of cardiovascular diseases]. Novosibirsk, Nauka Siberian branch Publ., 1991, 240 p.
  35. Lobanova I.V. Issledovaniya i standartizatsiya sbora, nastoya i sukhogo ekstrakta «Mirfazin». Avtoref. dis. … kand. farmats. nauk [Research and standardization of the collection, infusion and dry extract “Mirfazin”. Abstract of PhD thesis]. Moscow, 2001, 21 p.
  36. Lomachenko N.V, Bashirova P.M. Farmakologicheskie svoistva giperitsina (obzor) [Pharmacological properties of hypericin (review)]. Itogi biologicheskikh issledovanii Bashkirskogo universiteta za 1998 god [Results of biological research at Bashkir University in 1998]. Ufa, 1999, iss. 5, pp. 105–108.
  37. Lomachenko N.V. Nakoplenie fenol’nykh soedinenii rasteniem Hypericum perforatum L. v ekologo-tsenoticheskikh gradientakh: dis. … kand. biol. nauk [The accumulation of phenolic compounds by the plant Hypericum perforatum L. in ecological coenotic gradients. PhD thesis]. Ufa, 1998, 153 p.
  38. Loskutov I.A. Immunotropnaya aktivnost’ prirodnykh flavonoidov: avtoref. dis. … kand. med. nauk [Immunotropic activity of natural flavonoids. Abstract of PhD thesis]. Chelyabinsk, 1989, 23 p.
  39. Makarova M.N., Makarov V.G. Molekulyarnaya biologiya flavonoidov: (khimiya, biokhimiya, farmakologiya: rukovodstvo dlya vrachei [Molecular biology of flavonoids: chemistry, biochemistry, pharmacology: a guide for doctors ]. Petersburg, Lema Publ., 2010, 428 p.
  40. Maksyutina N.P., Koget T.A. Polifenoly travy Hypericum perforatum i preparata novoimanina [Polyphenols of the herb Hypericum perforatum and the drug Novoimanina]. Khimiya prirodnykh soedinenii [Chemistry of Natural Compounds], 1971, no. 5, pp. 363–367.
  41. Manolova N., Maksimova V. Lechebni rasteniya inkhibitory na virusy [Medicinal plants virus inhibitors]. Sofiya, 1988, 148 p.
  42. Makhlayuk V.P. Lekarstvennye rasteniya v narodnoi meditsine [Medicinal plants in traditional medicine]. Moscow, Niva Rossii Publ., 1992, 477 p.
  43. Mashkovskii M.D. Lekarstvennye sredstva: Posobie po farmakoterapii dlya vrachei: v 2 t. 8-e izd [Medicines: A guide to pharmacotherapy for doctors. 2 vols. 8th]. Moscow, Medicine Publ., 1977, vol. 1, 624 p.; vol. 2, 560 p.
  44. Belitskii G.A., Kirsanov K.I., Lesovskaya E.A., Yakubovskaya G. Mekhanizmy antikantserogennogo deistviya flavonoidov [Mechanisms of the anticancerogenic effect of flavonoids]. Uspekhi molekulyarnoi onkologii [Advances in Molecular Oncology], 2014, vol. 1, no. 1, pp. 56–58.
  45. Murav’eva D.A., Samylina I.A., Yakovlev G.P. 4-e izd., pererab. i dop [Pharmacognosy. 4th ed., revised and suppl.]. Moscow, Medicine Publ., 2002, 656 p.
  46. Nikolaeva V.G. Rasteniya, primenyaemye narodami SSSR pri zabolevaniyakh pecheni i zhelchevyvodyashchikh putei [Plants used by the peoples of the USSR in diseases of the liver and biliary tract]. Rastitel’nye resursy [Plant Resources and Environment], 1977, vol. 13, issue 2, pp. 396–403.
  47. Dobrovol’skii Yu.N., Diordiichuk V.V., Voitenko V.V. Otrezvlyayushchee deistvie vodnogo ekstrakta zveroboya prodyryavlennogo pri ostrom alkogol’nom otravlenii [The sobering effect of an aqueous extract of Hypericum perforatum in acute alcohol poisoning]. 2-ya respublikanskaya konferentsiya po meditsinskoi botanike [Proc. of 2nd Republican Conf. on Medical Botany]. Kiev, 1988, pp. 347–348.
  48. Levashova I.G., Sokirko V.I., Zhdanova V.P., Shatunova L.V. Otkhody zveroboya prodyryavlennogo kak istochnik biologicheski aktivnykh veshchestv [Waste of Hypericum perforatum as a source of biologically active substances]. 3-ya ukr. konf. po med. botanike: v 2 ch. [Proc. of 3rd Ukrainian Conf. on Medical Botany. 2 parts]. Kiev, 1992, part 1, pp. 90.
  49. Ponomareva A.G., Poverin D.I. Sbor lekarstvennykh trav dlya lecheniya sakharnogo diabeta «Lidiya 1, 2, 3» [Collection of medicinal herbs for the treatment of diabetes mellitus «Lydia 1, 2, 3»]. Patent RF, no. 2000802, 1993.
  50. Makeev B.A., Leont’ev A.I. Biologicheski aktivnoe veshchestvo, obladayushchee protivomikrobnoi, fagotsitarnoi, mitoticheskoi i antioksidantnoi aktivnost’yu [Biologically active substance with antimicrobial, phagocytic, mitotic and antioxidant activity]. Patent RF, no. 2008913, 1994.
  51. Kashkin N.I., Zabelina T.N. Veshchestvo, obladayushchee antiblasticheskoi aktivnost’yu [Antiblastic agent].Patent RF, no. 2008909, 1994.
  52. Plakhova N.B. Sravnitel’noe deistvie dubil’nykh rastenii, proizrastayushchikh v Sibiri, na dizenteriinuyu gruppu bakterii [The comparative effect of tannins plants in Siberia on the dysenteric group of bacteria]. Farmakologiya i toksikologiya [Pharmacology and Toxicology], 1954, vol. 17, no. 4, pp.39-42.
  53. Pravdivtseva O.E., Kurkin V.A. Sravnitel’noe issledovanie khimicheskogo sostava nadzemnoi chasti nekotorykh vidov Hypericum perforatum L. [Comparative study of the chemical composition of the aboveground parts of some species of Hypericum perforatum L.]. Khimiya rastitel’nogo syr’ya [Chemistry of Plant Raw Material], 2009, no. 1, pp. 79–82.
  54. Pravdivtseva O.E., Kurkin V.A. Steriny nadzemnoi chasti zveroboya prodyryavlennogo [Sterols of the aboveground part of Hypericum perforatum]. Khimiya rastitel’nogo syr’ya [Chemistry of Plant Raw Material], 2011, no. 4, pp. 333–334.
  55. Pravdivtseva O.E., Kurkin V.A. Issledovanie khimicheskogo sostava nadzemnoi chasti Hypericum perforatum L. [The study of the chemical composition of the aboveground part of Hypericum perforatum L.]. Meditsinskii al’manakh [Medical Almanac], 2012, no. 5(24), pp. 204–206.
  56. Razhinskaite D.K. Deistvuyushchie veshchestva zveroboya obyknovennogo [Active substances of Hypericum perforatum]. Trudy Akademii Nauk Litovskoi SSR. Ser. V. Vil’nyus [Bulletin of the Academy of Sciences of the Lithuanian SSR. Ser. V.], 1971, vol. 1, no. 54, pp. 89–98.
  57. Budantsev A.L. Rastitel’nye resursy Rossii i sopredel’nykh gosudarstv: Ch.1. Semeistva Lycopodiaceae-Ephedraceae, ch. 2. Dopolneniya k 17 vol. [Plant resources of Russia and neighboring states: Part 1. Families of Lycopodiaceae-Ephedraceae, Part 2. Supplements to 1-7 vol.]. Petersburg, Mir i semya-95 Publ., 1996, 571 p.
  58. Sokolov P.D. Rastitel’nye resursy SSSR: Tsvetkovye rasteniya, ikh khimicheskii sostav, ispol’zovanie; Semeistva Paeoniaceae-Thymelaeaceae [Plant resources of the USSR: Flowering plants, their chemical composition, use; Families Paeoniaceae-Thymelaeaceae]. Leningrad, Nauka Publ., 1986, 336 p.
  59. Red’ko I.G., Efimova T.V., Khalmatov Kh.Kh. Soki svezhei travy zveroboya i gryzhnika [Juices of fresh herb Hypericum and hernia]. Materialy yubileinoi respublikanskoi nauchnoi konferentsii farmatsevtov [Proc. of the Anniversary Republican Conf. of Pharmacists]. Tashkent, 1972, pp. 86–87.
  60. Rumyantseva Zh.I., Gudivok Ya.S. Poiski gepatoprotektorov sredi preparatov rastitel’nogo proiskhozhdeniya [Search for hepatoprotectors among herbal products]. Rastitel’nye resursy [Plant Resources and Environment], 1993, vol. 29, issue 1, pp.88-97.
  61. Smyshlyaeva A.V. Kudryashov Yu.B. Modifikatsiya luchevogo porazheniya zhivotnykh ekstraktom Hypericum prforatum L. Soobshch. 1 [Modification of radiation injury to animals with Hypericum prforatum L. extract. Message 1]. Biologicheskie nauki [Biological Sciences], 1992, no. 4, pp. 7–9.
  62. Sokolov S.Ya. Fitoterapiya i fitofarmakologiya [Herbal medicine and phytopharmacology]. Moscow, Medical News Agency Publ., 2000, 965 p.
  63. Talanov V.V., Trusov V.V., Filimonov M.A. Lekarstvennye rasteniya – bol’nomu sakharnym diabetom. Uchebnoe posobie dlya subordinatorov, internov, ordinatorov [Medicinal plants – for a patient with diabetes. The manual for subordinates, interns, residents]. Kazan, Kazan Medical University Publ., 1992, 48 p.
  64. Thomas C. Baghai, David S. Baldwin, Barbara Barrett, Pierre Baumann. Antidepressant medications and other treatments of depressive disorders: a CINP Task Force report based on review of evidence. Neuropsychopharmacology, 2007, vol. 10, pp. 1–207. doi: 10.1017/S14611455707008255. (Russ. Krasnova V.N., ed. Terapiya antidepressantami i drugie metody lecheniya depressivnykh rasstroistv: Doklad Rabochei gruppy CINP na osnove obzora dokazatel’nykh dannykh. Moscow, Moscow Research Institute of Psychiatry of Roszdrav Publ., 2008, 216 p.).
  65. Tikhonov V.N., Kalinkina G.I., Sal’nikova E.N. Lekarstvennye rasteniya, syr’e i fitopreparaty. Ch. 2 [Medicinal plants, raw materials and herbal remedies. Part 2]. Tomsk, Siberian State Medical University Publ., 2004, 148 p.
  66. Ushkalova A.V., Illarionova T.S. Effektivnost’ i bezopasnost’ antidepressivnykh i sedativnykh sredstv rastitel’nogo proiskhozhdeniya [Efficacy and safety of antidepressant and sedative products of plant origin]. Farmateka [Farmateka], 2007, no. 20, pp. 10–14.
  67. Faizullina R.R. Fitokhimicheskoe izuchenie zveroboya prodyryavlennogo (Hypericum perforatum L.) flory Bashkortostana i perspektivy sozdaniya na ego osnove novykh lekarstvennykh sredstv: avtoref. dis. … kand. farmats. nauk [The phytochemical study of Hypericum perforatum L. of Bashkortostan flora and the prospects for creating new drugs based on it. Abstract of PhD thesis]. Ufa, 2005, 21 p.
  68. Zhokhova E.V., Goncharov M.Yu., Povydysh M.N. Farmakognoziya [Pharmacognosy]. Moscow, GEOTAR-Media Publ., 2016, 544 p.
  69. Khalmatov Kh.Kh. Dikorastushchie lekarstvennye rasteniya Uzbekistana [Wild medicinal plants of Uzbekistan]. Tashkent, Uzbek SSR State Publ., 1964, 279 p.
  70. Khalmatov Kh.Kh. Rasteniya Uzbekistana s diureticheskim deistviem [Plants of Uzbekistan with diuretic action]. Tashkent, Medicine Uzbek SSR Publ., 1979, 180 p.
  71. Khalmatov Kh.Kh. Fitokhimicheskoe izuchenie nekotorykh sredneaziatskikh vidov zveroboya: avtoref. dis. … kand. farmats. nauk [Phytochemical study of some Central Asian species of Hypericum. Abstract of PhD thesis]. Tashkent, 1948, 6 p.
  72. Chaplinskaya M.G. Fitokhimicheskoe issledovanie travy zveroboya i izgotovlenie iz nee farmakologicheskikh preparatov: avtoref. dis. … kand. farmats. nauk [Phytochemical study of Hypericum herb and the manufacture of pharmacological preparations from it. Abstract of PhD thesis]. Lviv, 1959, 13 p.
  73. Yashin Ya.I., Vedenin A.N., Yashin A.Ya. Lekarstvennye preparaty, lekarstvennye rasteniya i BADy s antioksidantnoi aktivnost’yu [Medicines, medicinal plants and dietary supplements with antioxidant activity]. Sorbtsionnye i khromatograficheskie protsessy [Sorption and chromatographic processes], 2017, vol. 17, no. 3, pp. 496–505.
  74. Betty R.C., Trikojus V.M. Hypericum and a non-fluorescent photosensitive pigment from St. John’s wort (Hypericum perforatum). J. Exp. Biol. MED. Sci, 1943, vol. 21, pp. 175–182.
  75. Brockmann H., Pampus G. Die Isolierung des Pseudohypericins. Naturwissen-schaften, 1954, Jg. 41, H.4, S. 86–87.
  76. Chaloupka Roman. The effect of hypericin and hypocrellin-A on lipid membranes and membrane potential of 3T3 fibroblasts. Biochimica et Biophysica Acta, 1999, vol. 1418, pp. 39–47.
  77. Baser K.N.S., Ozek T., Nuriddinov H.R., Demirci A.B. Essential oils of two Hypericum species from Uzbekistan. Chemestry of Natural Compounds, 2002, vol. 38, no. 1, pp. 54–57.
  78. Gheorgia A., Jonescu-Matiu E., Boteanu S. Contributii la studiul uleirilor esentiale isolate din Hypericum prforatum L. si H. acutum L. Comun. bot. (RSR), 1969, vol. 8, pp. 119–124.
  79. Hobbs C., Johns St. Wort Hypericum perforatum L. Herbal Gram., 1989, no. 18, pp. 24–33.
  80. Demisch L., Holzl J., Gollink B., Kaczmarryk P. Identification of selective MAO type A inhibitors in Hypericum perforatum L. (hyperforat). Pharmacopsychiatry, 1989, vol. 22, no. 5, p. 194.
  81. Mathis C., Ourisson G. Etude chimio-taxonomique du genere Hypericum. Phytochemistry, 1964, vol. 3, no. 1, p. 115–131.
  82. Michaluk A. Badania nad flavonoidami w gatunkach rodzaju Hypericum L.: Leukoantocyajanidyny w Hypericum perforatum L. PAN, 1961, vol. 13, no. 1, pp. 81–87.
  83. Middieton E.Jr. Effect of plant flavonoids on immune and inflammatory cell functions. Exp. Med. Biol., 1998, vol. 439, pp. 175–182.
  84. Muller W.E., Singer A., Wonnemann M. Hyperforin – antidepressant activity by a novel mechanism of action. Pharmacopsychiatry, 2001, vol. 34, no. 1, pp. 98–102.
  85. Biber A., Fischer H., Romer A., Chatterjee S.S. Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers. Pharmacopsychiatry, 1998, vol. 31, no. 1, pp. 36–43.
  86. Parvez M.K.., Rehman T., Alam P., Alqasoumi I. et al. Plant-derived antiviral drugs as novel hepatitis B virus inhibitors: Cell culture and molecular docking study. Saudi Pharm J., 2019, vol. 27, no. 3, pp. 389–400. DOI: 10.1016/j.jsps.2018.12.008.

About authors

Nalimova Natalia V.
Candidate of Biological Sciences, Associate Professor, Department of Medical Biology with course of Microbiology and Virology, Chuvash State University, Russia, Cheboksary (natalya_rgsu@mail.ru)
Efeikina Nadezhda B.
Candidate of Biological Sciences, Associate Professor, Department of Medical Biology with course of Microbiology and Virology, Chuvash State University, Russia, Cheboksary (nadezhdaefeykina@yandex.ru)

Article link

Nalimova N., Efeykina N. The Content of Biologically Active Substances in Hypericum Perforatum L. and the Pharmacotherapeutic Effect of Drugs Based on it (Review) [Electronic resource] // Acta medica Eurasica. – 2019. – №3. P. 24-36. – URL: http://acta-medica-eurasica.ru/en/single/2019/3/4/.