Shumilova N., Pavlova S.
Glyphosine derivatives: glycemic and non-clycemic effects
In the world there is a tendency of increase in the incidence of type 2 diabetes. The search for new hypoglycemic agents with maximum efficiency and minimal side effects continues. There appeared a new class of hypoglycemic agents – inhibitors of sodium/glucose cotransporter of type 2 in the kidneys (SGLT2), which reduce plasma glucose levels by reducing its reabsorption in the proximal renal tubules. Decrease of glucose in blood occurs independently of insulin and pancreatic beta-cells’ functioning. In Russia Dapagliflozinum, Empagliflozinum, Canagliflozinum are registered. Clinical trials of these drugs have shown their effectiveness in reducing glycemia and glycated hemoglobin in type 2 diabetic patients. In addition, glyphosine derivatives showed a number of positive non-glycemic effects: decrease in body weight, in the risk of cardiovascular complications in type 2 diabetic patients. Glyphosine derivatives are characterized by a low risk of adverse effects. Glyphosine derivatives are well tolerated by patients and rarely cause hypoglycemic states in patients with type 2 diabetes. The most frequent complications were urinary tract infections, and the rarest was ketoacidosis.
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- Shumilova Nadezhda A.
- Senior Lecturer, Pharmacology, Clinical Pharmacology and Biochemistry Department, Chuvash State University, Russia, Cheboksary (firstname.lastname@example.org; )
- Pavlova Svetlana I.
- Doctor of Medical Sciences, Head of the Department of Pharmacology, Clinical Pharmacology and Biochemistry, Chuvash State University, Russia, Cheboksary (email@example.com; ORCID: https://orcid.org/0000-0001-9976-7866)
Shumilova N., Pavlova S. Glyphosine derivatives: glycemic and non-clycemic effects [Electronic resource] // Acta medica Eurasica. – 2019. – №1. P. 44-51. – URL: http://acta-medica-eurasica.ru/en/single/2019/1/6/.