Single article

Denisova T., Samoylova A., Vasilyeva E., Gerasimova L.

The influence of vitamin D on reproductive health (literature review)

Keywords: vitamin D deficiency, female reproductive health, pregnancy, fetus and newborn development, prevention

Currently, no less than 30-50% of the world's population have a low supply of vitamin D. According to modern concepts, vitamin D plays an important role in numerous physiological processes, turning into active metabolites in the body. Renal production of vitamin D performs "classical" functions, affects blood pressure regulation and has an immunotropic and neuroprotective effect. Extrarenal production implements other biological effects: regulation of cellular growth and differentiation, support of protein synthesis and breakdown processes, anti-inflammatory and immunomodulating properties, muscular function control, insulin secretion, blood coagulation, central nervous system activity, regulation of gametogenesis, apoptosis and embryogenesis, lowering the risk of developing autoimmune diseases. From the literature data it is known that in the tissues of reproductive organs – in the ovaries, uterus, placenta and pituitary gland – vitamin D nuclear receptor (VDR) and 1α-hydroxylase were found. In this regard, association of the role of vitamin D and the condition of female reproductive health, the course of pregnancy and childbirth is obvious. Against the background of vitamin D deficiency during pregnancy, the rate of cesarean section is 4 times higher than that in pregnant women with normal vitamin D levels as well as the frequency of preterm labor and anomalies in uterine contractile activity, which is associated with a low level of ionized calcium in myocytes, since the release of ionized calcium is carried out under the influence of vitamin D. Vitamin D is involved in programming fetal and newborn development, the level of vitamin D in pregnant women has a direct relationship with the body weight of the child at birth and his head circumference, hypovitaminosis D of the mother has a significant effect on the development of bone tissue and congenital immunity in the fetus, which is of great importance for formation of chronic diseases soon after birth, as well as at a later age. Replenishment of vitamin D deficiency has very broad prospects for optimizing the health status of women and children, and may be one of the most important preventive health programs.

References

  1. Shikh E.V., Milotova N.M. Rol’ polimorfizma gena VDR, kodiruyushchego retseptor vitamina D, v patogeneze arterial’noi gipertonii [The role of coding vitamin D receptor VDR gene polymorphism in pathogenesis of hypertension]. Biomeditsina, 2009, vol. 1, no. 1, pp. 55–67.
  2. Alpert P.T., Shaikh U. The effects of vitamin D deficiency and insufficiency on the endocrine and paracrine systems. Biological Research for Nursing, 2007, vol. 9, no. 2, pp. 117– DOI: 10.1177/1099800407308057.
  3. Baker A.M., Haeri S., Camargo C.A., Stuebe A.M., Boggess K.A. First-trimester maternal vitamin D status and risk of gestational diabetes (GDM): A nested case-control study. Diabetes/Metabolism Research and Reviews, 2012, vol. 28, no. 2, pp. 164–168. DOI:10.1002/dmrr.1282.
  4. Bodnar L.M., Catov J.M., Simhan H.N. Maternal vitamin D deficiency increases the risk of preeclampsia. Journal of Clinical Endocrinology and Metabolism, 2007, vol. 92, no. 9, pp. 3517–3522. DOI: 10.1210/jc.2007-0718.
  5. Bodnar L.M., Simhan H.N. The prevalence of preterm birth and season of conception. Paediatric and Perinatal Epidemiology, 2008, vol. 22, no. 6, pp. 538–545. DOI: 10.1111/j.1365-3016.2008.00971.x.
  6. Bodnar L.M., Platt R.W., Simhan H.N. Early-pregnancy vitamin D deficiency and risk of preterm birth subtypes. Obstet Gynecol, 2015, vol. 125(2), pp. 439–447. DOI: 10.1097/ AQG.0000000000000621.
  7. Choi R., Kim S., Yoo H., Cho Y.Y., Kim S.W., Chung J.H., et al. High prevalence of vitamin D deficiency in pregnant Korean women: the first trimester and the winter season as risk factors for vitamin D deficiency. Nutrients, 2015, vol. 7, pp. 3427–3448. DOI: 10.3390/nu7053427.
  8. Flood-Nichols S.K., Tinnemore D., Huang R.R., Napolitano P.G., Ippolito D.L. Vitamin D deficiency in early pregnancy. PLoS One, 2015, vol. 10(4), p. e0123763. DOI: 10.1371/journal.pone.0123763.
  9. Gale C.R., Robinson S.M.,Harvey N.C., et al. Maternal vitamin D status during pregnancy and child outcomes. European Journal of Clinical Nutrition, 2008, vol. 62, no. 1, pp. 68–77. DOI: 10.1038/sj.ejcn.1602680.
  10. Grundmann M., von Versen-Höynck F. Vitamin D – roles in women’s reproductive health? Reproductive Biology and Endocrinology, 2011, vol. 9, no. 2, art. no. 146. DOI: 10.1186/1477-7827-9-146.
  11. Gupta V. Vitamin D: Extra-skeletal effects. J Med Nutr Nutraceut, 2012, vol. 1, pp. 17–26.
  12. Harvey N.C., Holroyd C., Ntani G., Javaid K., Cooper P., Moon R. et al. Vitamin D supplementation in pregnancy: a systematic review. Health Technol Assess, 2014, vol. 18(45), pp. 1–190. DOI: 10.3310/hta18450 PMID: 25025896.
  13. Holick M.F. Sunlight and Vitamin D for Bone Health and Prevention of Autoimmune Diseases, Cancers, and Cardiovascular Disease. The American Journal of Clinical Nutrition, 2004, vol. 80, pp. S1678–S1688.
  14. Holick M.F. et al. Guidelines on Vitamin D Deficiency. J Clin Endocrinol Metab, 2011, vol. 96(7).
  15. Haugen M., Brantsaeter A.L., Trogstad L. et al. Vitamin D supplementation and reduced risk of preeclampsia in nulliparous women. Epidemiology, 2009, vol. 20, no. 5, pp. 720–726.
  16. Heaney R.P. Vitamin D in health and disease. Clinical Journal of the American Society of Nephrology, 2008, vol. 3, no. 5, pp. 1535–1541. DOI: 10.2215/CJN.01160308.
  17. Hewison M. Vitamin D and the immune system: New perspectives on an old theme. Endocrinology and Metabolism Clinics of North America, 2010, vol. 39, no. 2, pp. 365–379. DOI: 10.1016/j.ecl.2010.02.010.
  18. Holick M.F. Medical progress: vitamin D deficiency. New England Journal of Medicine, 2007, vol. 357, no. 3, pp. 266–281. DOI: 10.1056/NEJMra070553.
  19. Hollis B.W., Johnson D., Hulsey T.C. et al. Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. Journal of Bone and Mineral Research, 2011, vol. 26, no. 10, pp. 2341—2357. DOI: 10.1002/jbmr.463.
  20. Hollis B.W., Wagner C.L. Vitamin D and Pregnancy: Skeletal Effects, Nonskeletal Effects, and Birth Outcomes. Calcified Tissue International, 2013, vol. 92, pp. 128–139. Available at: http://dx.doi.org/ 10.1007/s00223-012-9607-4.
  21. Hollis B.W., Johnson D., Hulsey T.C., Ebeling M., Wagner C.L. Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res. 2011, vol. 26 (10), pp. 2341–2357. DOI: 10.1002/ibmr.463.
  22. Holmes V.A., Barnes M.S., Alexander H.D., McFaul P., Wallace J.M.W. Vitamin D deficiency and insufficiency in pregnant women: A longitudinal study. British Journal of Nutrition, 2009, vol. 102, no. 6, pp. 876–881. DOI: 10.1017/S0007114509297236.
  23. Hossain N., Kanani F.H., Ramzan S., Kausar R., Ayaz S., Khanani R. et al. Obstetric and neonatal outcomes of maternal vitamin D supplementation: results of an open-label, randomized controlled trial of antenatal vitamin D supplementation in Pakistani women. J Clin Endocrinol Metab., 2014, vol. 99(7), pp. 2448–2455. DOI: 10.1210/jc.2013-3491.
  24. Hossein-Nezhad A., Holick M.F. Vitamin D for health: A global perspective. Mayo Clinic Proceedings, 2013, vol. 88, no. 7, pp. 720-755. DOI: 10.1016/j.mayocp.2013.05.011.
  25. Johnson D.D., Wagner C.L., Hulsey T.C., Vitamin D deficiency and insufficiency is common during pregnancy. American Journal of Perinatology, 2011, vol. 28, no.1, pp. 7-12. DOI: 10.1055/s-0030-1262505.
  26. Castro L.C. The vitamin D endocrine system Arq. Bras Endocrinol Metabol.,2011, vol. 55(8), pp. 566–575.
  27. Kebashni Thandrayen, John M. Pettifor. Endocrinology and Metabolism. Clinics of North Americа, 2010, vol. 39, iss. 2, pp. 303–320.
  28. Kovacs C.S. Vitamin D in during pregnancy and lactation: Maternal, fetal and neonatal outcomes from human and animal studies. American Journal of Clinical Nutrition, 2008, vol. 88, no. 2, pp. 520S–528S.
  29. Lanham-New S.A., Buttriss J.L., Miles L.M., et al. Proceedings of the rank forum on vitamin D. British Journal of Nutrition, 2011, vol. 105, no. 1, pp. 144–156. DOI: 10.1017/S0007114510002576.
  30. Lapillonne A. Vitamin D deficiency during pregnancy may impair maternal and fetal outcomes. Medical Hypotheses, 2010, vol. 74, no. 1, pp. 71–75. DOI: 10.1016/j.mehy.2009.07.054.
  31. Leffelaar E.R., Vrijkotte T.G.M., Van Eijsden M. Maternal early pregnancy vitamin D status in relation to fetal and neonatal growth: Results of the multi-ethnic Amsterdam Born Children and their Development cohort. British Journal of Nutrition, 2010, vol. 104, no. 1, pp. 108–117. DOI: 10.1017/S000711451000022X.
  32. Lewis S., Lucas R.M., Halliday J., Ponsonby A. -L. Vitamin D deficiency and pregnancy: From preconception to birth. Molecular Nutrition and Food Research, 2010, vol. 54, no. 8, pp. 1092–1102. DOI: 10.1002/mnfr.201000044.
  33. Liu N.Q., Kaplan A.T., Lagishetty V., et al. Vitamin D and the regulation of placental inflammation. Journal of Immunology, 2011, vol. 186, no. 10, pp. 5968–5974. DOI: 10.4049/jimmunol.1003332.
  34. Lucas R.M., Ponsonby A. -L., Pasco J.A., Morley R. Future health implications of prenatal and early-life vitamin D status. Nutrition Reviews, 2008, vol. 66, no. 12, pp. 710–720. DOI: 10.1111/j.1753-4887.2008.00126.x.
  35. Martínez-Miguel P., Valdivielso J.M., Medrano-Andrés D.,Román-García P., Cano-Peñalver J.L., Rodríguez-Puyol M., Rodríguez-Puyol D., López-Ongil S. The active form of vitamin D, calcitriol, induces a complex dual upregulation of endothelin and nitric oxide in cultured endothelial cells. J. Physiol. Endocrinol. Metab., 2014, vol. 307, no. 12, pp. 1085–1096.
  36. Mirzakhani H., Litonjua A.A., McElrath TF., O’Connor G., Lee-Parritz A., Iverson R. et al. Early pregnancy vitamin D status and risk of preeclampsia. J Clin Invest., 2016, Dec. 1, vol. 126(12), pp. 4702–4715. DOI: 10.1172/JCI89031.
  37. Ota K., Dambaeva S., Han A.R., Beaman K., Gilman-Sachs A., Kwak-Kim J. Vitamin D deficiency may be a risk factor for recurrent pregnancy losses by increasing cellular immunity and autoimmunity. Hum Reprod., 2014, vol. 29, pp. 208–219. DOI: 10.1093/humrep/det424.
  38. Phend C. Vitamin D May Help in HF. MedPage Today, 2012, May 22. Available at: www.medpagetoday.com/MeetingCoverage/HFC/32840.
  39. Powe C.E., Seely E.W., Rana S. et al. First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia. Hypertension, 2010, vol. 56, no. 4, pp. 758–763. DOI: 10.1161/HYPERTENSIONAHA.110.158238.
  40. Robinson C.J., Alanis M.C., Wagner C.L., Hollis B.W., Johnson D.D. Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia. American Journal of Obstetrics and Gynecology, 2010, vol. 203, no. 4, pp. 366e1–366e6. DOI: 10.1016/j.ajog.2010.06.036.
  41. Robinson C.J., Wagner C.L., Hollis B.W., Baatz J.E., Johnson D.D. Maternal vitamin D and fetal growth in early-onset severe preeclampsia. American Journal of Obstetrics and Gynecology, 2011, vol. 204, no. 6, pp. 556e1–556e4. DOI: 10.1016/j.ajog.2011.03.022.
  42. Rodriguez A., Garcia-Esteban R., Basterretxea M., Lertxundi A., Rodriguez-Bernal C., Iniguez C. et al. Associations of maternal circulating 25-hydroxyvitamin D3 concentration with pregnancy and birth outcomes. BJOG, 2015, vol. 122(12), pp. 1695–1704. DOI: 10.1111/1471-0528.13074PMID: 25208685.
  43. Sablok A., Batra A., Thariani K., Batra A., Bharti R., Aggarwal A.R. et al. Supplementation of vitamin D in pregnancy and its correlation with feto-maternal outcome. Clin Endocrinol (Oxf), 2015, vol. 83(4), pp. 536–541.
  44. Thorne-Lymana A., Fawzi W.W. Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis. Paediatr Perinat Epidemiol., 2012, vol. 26(01), pp. 75–90. DOI:10.1111/j.1365-3016.2012.01283.x.
  45. Wagner C., McNeil R., Ebeling M. et al. Analysis of Two Randomized Vitamin D3 Supplementation Trials during Pregnancy: Health Characteristics and Outcomes. Medical University of South Carolina, Charleston, SC, USA. 2012. Unpublished work.
  46. Wagner C.L., Baggerly C., McDonnell S.L., Baggerly L., Hamilton S.A., Winkler J. et al. Post-hoc comparison of vitamin D status at three time points during pregnancy demonstrates lower risk of preterm birth with higher vitamin D closer to delivery. J Steroid Biochem Mol Biol., 2015, vol. 148, pp. 256–260. DOI: 10. 1016/Msbmb.2014.11.013.
  47. Wehr E., Pieber T.R., Obermayer-Pietsch B. Effect of vitamin D3 treatment on glucose metabolism and menstrual frequency in polycystic ovary syndrome women: A pilot study. Journal of Endocrinological Investigation, 2011, vol. 34, no. 10, pp. 757–763. DOI: 10.3275/7748.
  48. Guideline: Vitamin D supplementation in pregnant women. Geneva, World Health Organization, 2012.
  49. Zhang C., Qiu, C., Hu F.B. et al. Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PLoS ONE, 2008, vol. 3, no. 11, art. no. e3753. DOI: 10.1371/journal.pone.0003753

About authors

Samoilova Alla Vladimirovna
doctor of medicine, professor, obstetrics and gynecology department head , Chuvash State University, Russia, Cheboksary (allasamoi@mail.ru)
Vasilieva Elvira N.
Candidate of Medical Sciences, Associate Professor of the Department of Obstetrics and Gynecology, Chuvash State University, Russia, Cheboksary (elnikvas@mail.ru)
Gerasimova Ludmila Ivanovna
doctor of medical sciences, professor, public health and health organization department head, rector, Institute for Advanced Medical Studies, Russia, Cheboksary
Denisova Tamara G.
Doctor of Medical Sciences, Professor, Department of Obstetrics and Gynecology, Chuvash State University, Russia, Cheboksary (tomadenisova@rambler.ru)

Article link

Denisova T., Samoylova A., Vasilyeva E., Gerasimova L. The influence of vitamin D on reproductive health (literature review) [Electronic resource] // Acta medica Eurasica. – 2018. – №3. P. 9-19. – URL: http://acta-medica-eurasica.ru/en/single/2018/3/2/.