Single article

Zakharova V., Karzakova L.

The correction of microbiocenosis in patients with ulcerous disease of the bulb of the duodenum associated with helicobacter pylori infection

Keywords: ulcerous disease of the bulb of the duodenum, Helicobacter pylori, intestinal microflora, dysbiosis

The research objective was to study the efficiency of using probiotic medicines in complex treatment of ulcerous disease of the bulb of the duodenum associated with Helicobacter pylori infection. The research included 30 patients with ulcerous disease of the bulb of the duodenum which was for the first time diagnosed with esophagogastroduodenoscopy at the outpatient stage and confirmed Helicobacter pylori infection. The patients were divided into 2 groups: the first group of patients received standard eradication therapy of the first line in the composition of amoxicillin 2 g per day, clarithromycin 1 g per day and omeprazole 40 mg per day for 10 days, the second group – standard therapy in combination with the medicine «Linex» 2 capsules 3 times a day for 14 days. In patients with ulcerous disease of the bulb of the duodenum associated with Helicobacter pylori infection, dysbiotic changes of different degree of severity have been detected by the type of decrease in the presence of normal intestinal microflora and increase in the population of conditionally pathogenic bacteria. Standard eradication therapy leads to aggravation of the initial dysbiosis. Inclusion in the scheme of therapy of the drug «Linex» improves the tolerability of therapy and corrects the initial dysbiotic changes.

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About authors

Karzakova Luiza M.
Doctor of Medical Sciences, Professor, Head of Internal Diseases Department, Chuvash State University, Russia, Cheboksary (luizak58@mail.ru)
Zakharova Valentina Vladimirovna
gastroenterologist, Central City Hospital, Russia, Cheboksary (tinaz@bk.ru)

Article link

Zakharova V., Karzakova L. The correction of microbiocenosis in patients with ulcerous disease of the bulb of the duodenum associated with helicobacter pylori infection [Electronic resource] // Acta medica Eurasica. – 2017. – №2. P. 6-12. – URL: http://acta-medica-eurasica.ru/en/single/2017/2/2/