Andreeva N., Pavlova S.
Anty-cancer activity of syntetic flavonoid in vitro
In terms of the research and development of new targeted anticancer drugs in recent years plant polyphenols (flavonoids) have attracted much attention. Studies have recently shown that flavonoids can affect the molecular mechanisms of oncogenic processes. Therefore the aim of this paper was to study the antitumor activity of synthetic chalcone (SCh, flavonoid with open pyran ring) 1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one in vitro using human tumor cell cultures such as MOLT-4 and HeLa. The impact of SCh to cell viability was tested by MTT test and by the evaluation of the absolute number of tumor cells during SCh exposition, proapoptogenic effect of SCh was tested by flow cytometry. It was found that the SCh time- and dose-dependent inhibits tumor cell grew and induces apoptosis in the test culture cells. Analysis of the data suggests that apoptogenic action of SCh is related to cell cycle arrest in G2 / M phase. Thus, further study of anticancer properties of 1-(2-hydroxyphenyl)-3-(4-methoxyphenyl) prop-2-en-1-one seems to be promising in terms of developing a new antitumor agent.
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- Andreeva Natalia Alexandrovna
- medical faculty 6th year student, Chuvash State University, Russia, Cheboksary (firstname.lastname@example.org; )
- Pavlova Svetlana I.
- Doctor of Medical Sciences, Head of the Department of Pharmacology, Clinical Pharmacology and Biochemistry, Chuvash State University, Russia, Cheboksary (email@example.com; ORCID: https://orcid.org/0000-0001-9976-7866)
Andreeva N., Pavlova S. Anty-cancer activity of syntetic flavonoid in vitro [Electronic resource] // Acta medica Eurasica. – 2016. – №1. P. 41-49. – URL: http://acta-medica-eurasica.ru/en/single/2016/1/6/.