Morphological and densitometric parameters of ovarian tumor stroma in predicting tumor progression in case of serous ovarian carcinoma
The aim of this work is to determine the role of morphometric characteristics of the primary tumor stroma in the possibility of subsequent development of malignant tumor metastases. The investigation is based on the surgical biopsy material taken from 92 patients with ovarian cancer. Quantimetrix was carried out on Leica REICHERT POLIVAR 2 microscope with the use of Quantimet 500 C (Leica) digital image analysis system. Metastatic serous ovarian carcinomas are characterized by extensive areas of necrosis and parenchyma. An increased risk of developing tumor deposits is conjugated with the decreasing cross-sectional area of newly formed vessels. The growth of highly fractionated edema of the stroma significantly increases the likelihood of implantation metastasis. The collagen fibers of the stroma of the female gonads metastatic carcinoma are less mature and, definitely, significantly homogeneous.
- Novichkov Evgeny Vladimirovich
- candidate of medical sciences, pathophysiology, pathoanatomy with clinical pathoanatomy and forensic medicine department associate professor, Chuvash State University, Russia, Cheboksary )
Novichkov E. Morphological and densitometric parameters of ovarian tumor stroma in predicting tumor progression in case of serous ovarian carcinoma [Electronic resource] // Acta medica Eurasica. – 2015. – №2. P. . – URL: http://acta-medica-eurasica.ru/en/single/2015/2/5/.