UDC: 599.323.4-147.3-147.6.044
BBC: Е623.362.423*697.5*737.13-64
Kostrova O., Merkulova L., Kotyolkina A., Stomenskaya I., Struchko G., Mikhailova M.
Morphofunctional changes of adrenal glands and thymus in rats after carcinogen N-methyl-N-nitrosourea administration
Keywords: adrenal, thymus, carcinogenesis, biogenic amines, luminescent granule cells, thymus accidental transformation
The aim of this work was to study the morphological and functional characteristics of adrenal glands and thymus of 22 white female rats when administered N-methyl-N-nitrosourea. Using luminescent-histochemical and general histological method revealed that the introduction of a carcinogen causes in the thymus, an increase in the number of luminescent granule cells, multidirectional changes in the level of biogenic amines, reduction in area and thickness of the cerebral cortex, which indicates the development of the thymus accidental transformation. In the adrenal glands there are an increase in the number of luminescent cells, a significant increase in the thickness of cortex, as well as changes in the content of biogenic amines. The interaction between the thymus and the adrenal glands is mediated by the cells of APUD series, which include granular luminescent cells able to secret biogenic amines.
References
- Samotrueva M.A., Teplyi D.L., Tyurenkov I.N. Puti realizatsii neiro–immuno–endokrinnykh vzaimodeistvii [Ways of neuro-immuno-endocrine interactions realization]. Estestvennye nauki [Natural sciences]. 2009, no.4, рр. 112–130.
- Struchko G.Yu., Merkulova L.M., Moskvichev E.V., Kostrova O.Yu., Mikhailova M.N., Mukhammad Z., Bessonova K.V. Morfologicheskie izmeneniya timusa posle primeneniya polioksidoniya [Morphological changes of thymus after use polioxidonium] Fundamental‘nye issledovaniy [Fundamental research], 2012, no.5-1, pp. 197–202.
- Shilov Yu.I. Rol’ adrenergicheskikh mekhanizmov v realizatsii immunomoduliruyushchikh effektov glyukokortikoidov pri stresse [The role of adrenergic mechanisms in realization of immunomodulating effects of glucocorticoids under stress]. Vestnik Ural’skoi med. akademii nauk [Bulletin of the Ural Academy of Medical Sciences], 2004, no. 4, pp. 87–93.
- Elenkov I.J. Neurohormonal-cytokine interactions: implications for inflammation, common human diseases and well-being. Neurochem Int., 2008, vol. 52(1-2), pp. 40–51.
About authors
- Kostrova Olga Yu.
- Candidate of Medical Sciences, Assistant Professor, Head of Department of the Instrumental Diagnostics with a Course of Phthisiology, Chuvash State University, Russia, Cheboksary (evkbiz@yandex.ru; ORCID: https://orcid.org/0000-0002-7057-9834)
- Merkulova Larisa M.
- Doctor of Medical Sciences, Professor of Normal and Topographic Anatomy Department, Chuvash State University, Russia, Cheboksary (merkulova192@mail.ru; )
- Kotelkina Anastasia
- Assistant Lecturer of Normal and Topographic Anatomy Department, Chuvash State University, Russia, Cheboksary (ds6426@chebnet.com; )
- Stomenskaya Irina S.
- Candidate of Medical Sciences, Assistant Professor, Department of the Instrumental Diagnostics with a Course of Phthisiology, Chuvash State University, Russia, Cheboksary (irina.stomenskaja@gmail.com; ORCID: https://orcid.org/0000-0001-7332-4477)
- Struchko Gleb Yu.
- Doctor of Medical Sciences, Professor, Head of Normal and Topographic Anatomy Department, Chuvash State University, Russia, Cheboksary (glebstr@mail.ru; ORCID: https://orcid.org/0000-0002-0549-5116)
- Mikhailova Marina A.
- Candidate of Medical Sciences, Assistant Professor, Normal and Topographic Anatomy Department, Chuvash State University, Russia, Cheboksary (mar3007@mail.ru; )
Article link
Kostrova O., Merkulova L., Kotyolkina A., Stomenskaya I., Struchko G., Mikhailova M. Morphofunctional changes of adrenal glands and thymus in rats after carcinogen N-methyl-N-nitrosourea administration [Electronic resource] // Acta medica Eurasica. – 2016. – №3. P. 49-53. – URL: https://acta-medica-eurasica.ru/en/single/2016/3/8/.