Melnikova O., Sergeeva V.

Immunohistochemical methods in revealing cd4⁺ spleen cells after prolonged use of calcium

Keywords: spleen, calcium, immunohistochemistry, CD4+ cells

Immunohistochemical reaction was used to study six different morphotypes of CD4⁺ cells in white and red pulp, marginal sinuses, spleen trabeculae of intact rats and experimental rats after they had been on a calcium-rich diet. The total number of CD4⁺ cells decreased after a 60-day calcium-rich diet, however they appeared in small numbers in periarterial and reactive zones. Our study shows that calcium has immunomodulatory effect on the spleen CD4

About authors

Sergeeva Valentina E.

Doctor of Biological Sciences, Professor, Department of Medical Biology with a course in Microbiology and Virology, Chuvash State University, Russia, Cheboksary (kaf-biology@yandex.ru; ORCID: https://orcid.org/0000-0003-3471-5226)

Melnikova Olga Vladimirovna

medical biology with microbiology and virology course department graduate student, Chuvash State University, The Republic of Uzbekistan, Cheboksary )

Article link

Melnikova O., Sergeeva V. Immunohistochemical methods in revealing cd4⁺ spleen cells after prolonged use of calcium [Electronic resource] // Acta medica Eurasica. – 2015. – №1. P. . – URL: https://acta-medica-eurasica.ru/en/single/2015/1/3/.