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Солёнова Е.А., Николаевна Величковска Л.Н.

Флавоноиды. Перспективы применения в антимикробной терапии

Ключевые слова: антимикробная терапия, резистентность, чувствительность, Escherichia Coli, Staphylococcus Aureus

Представлены результаты литературного обзора антимикробной активности флавоноидов, выделенных из лекарственных растений. Проведен анализ литературных источников на предмет поиска антимикробных свойств флавоноидов в отношении E. Coli, S. Aureus как наиболее быстро развивающих резистентность микроорганизмов в современных условиях. Проведена сравнительная характеристика чувствительности данных микроорганизмов к флавоноидам, оценена перспектива внедрения в качестве средств, дополняющих антимикробную терапию.

Solyenova E., NikolaevnА Velichkovska L.

Flavonoids. prospects of their use in antimicrobial therapy

Keywords: antimicrobial therapy, resistance, sensitivity, Escherichia Coli, Staphylococcus Aureus

The results of literature review on antimicrobial activity of flavonoids extracted from medicinal plants are presented. An analysis of literature sources with respect to searching antimicrobial properties of flavonoids against E. Coli, S. Aureus as microorganisms the most rapidly developing resistance in modern conditions was carried out. A comparative analysis of the given microorganisms’ sensitivity to flavonoids was carried out, and the prospects of their introduction as a complement to antimicrobial therapy were evaluated.

Литература

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  23. Hendrich A.B., Malon R., Pola A., Shirataki Y., Motohashi N., Michalak K. Differential interaction of Sophora isoflavonoids with lipid bilayers. J. Pharm. Sci., 2002, vol. 16, pp. 201–208.
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  34. Tamura M., Saito H., Kikuchi K., Ishigami T., Toyama Y., Takami M., Ochiai K. Antimicrobial activity of Gel-entrapped catechins toward oral microorganisms. Pharm. Bull., 2011, vol. 34, pp. 638–643.
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  36. Wang Q., Wang H., Xie M. Antibacterial mechanism of soybean isoflavone on Staphylococcus aureus. Microbiol., 2010, vol. 192, pp. 893–898.
  37. Williams C. Healthy eating: clarifying advice about fruit and vege-tables. BMJ, 1995, vol. 310, pp. 1453–1455.
  38. Wu D., Kong Y., Han C., Chen J., Hu L., Jiang H., Shen X. D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin. J. Antimicrob. Agents, 2008, vol. 32, pp. 421–426.
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  40. Zhang F., Luo S.Y., Ye Y.B., Zhao W.H., Sun X.G., Wang Z.Q., Li R., Sun Y.H., Tian W.X., Zhang Y.X. The antibacterial efficacy of an aceraceous plant [Shantung maple (Acer truncatum Bunge)] may be related to inhibition of bacterial beta-oxoacyl-acyl carrier protein reductase (FabG). Appl. Biochem., 2008, vol. 51, pp. 73–78.

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  14. Chinnam N., Dadi P.K., Sabri S.A., Ahmad M., Kabir M.A., Ahmad Z. Dietary bioflavonoids inhibit Escherichia coli ATP synthase in a differential manner. J. Biol. Macromol., 2010, vol. 6, pp. 478–486.
  15. Cushnie T.P., Lamb A.J. Detection of galangin-induced cytoplasmic membrane damage in Staphylococcus aureus by measuring potassium loss. Ethnopharmacol., 2005, vol. 101, pp. 243–248.
  16. Eumkeb G., Sakdarat S., Siriwong S. Reversing beta-lactam antibiotic resistance of Staphylococcus aureus with galangin from Alpinia officinarum Hance and synergism with ceftazidime. Phytomedicine, 2010, vol. 18, pp. 40–45.
  17. Ferrazzano G.F., Amato I., Ingenito A., Zarrelli A., Pinto G., Pollio A. Plant polyphenols and their anti-cariogenic properties: a review. Molecules, 2011, vol. 16, pp. 1486–1507.
  18. Gould K.S., Lister C. Flavonoid functions in plants, in Ande-sen. Chemistry, biochemistry and applica-tions, Boca Raton, 2006, vol. 8, pp. 397–441.
  19. Gradisar H., Pristovsek P., Plaper A., Jerala R. Green tea catechins inhibit bacterial DNA gyrase by interaction with its ATP binding site. Med. Chem., 2007, vol. 50, pp. 264–271.
  20. Haraguchi H., Tanimoto K., Tamura Y., Mizutani K., Kinoshita T. Mode of antibacterial action of retrochalcones from Glycyrrhiza inflate. Phytochemistry, 1998, vol. 48, pp. 125–129.
  21. Hatano T., Shintani Y., Aga Y., Shiota S., Tsuchiya T., Yoshida T. Phenolic constituents of licorice. VIII. Structures of glicophenone and glicoisoflavanone, and effects of licorice phenolics on methicillin-resistant Staphylococcus aureus. Chem Pharm. Bull. (Tokyo), 2000, vol. 48, pp. 1286–1292.
  22. Hemaiswarya S., Kruthiventi A.K., Doble M. Synergism between natural products and antibiotics against infectious diseases. Phytomedicine, 2008, vol. 15, pp. 639–652.
  23. Hendrich A.B., Malon R., Pola A., Shirataki Y., Motohashi N., Michalak K. Differential interaction of Sophora isoflavonoids with lipid bilayers. J. Pharm. Sci., 2002, vol. 16, pp. 201–208.
  24. Jeong K.W., Lee J.Y., Kang D.I., Lee J.U., Shin S.Y., Kim Y. Screening of flavonoids as candidate antibiotics against Enterococcus faecalis. Nat. Prod., 2009, vol. 72, pp. 719–724.
  25. Khokhar S., Magnusdottir S.G. Total phenol, catechin, and caffeine contents of teas commonly consumed in the United kingdom. Agric. Food Chem., 2002, vol. 50, pp. 565–570.
  26. Kromann H., Larsen M., Boesen T., Schonning K., Nielsen S.F. Synthesis of prenylated benzaldehydes and their use in the synthesis of analogues of licochalcone A. J. Med. Chem., 2004, vol. 39, pp. 993–1000.
  27. Li-Weber M. New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treat. Rev., 2009, vol. 35, pp. 57–68.
  28. Oktyabrsky O., Vysochina G., Muzyka N., Samoilova Z., Kukushkina T., Smirnova G. Assessment of anti-oxidant activity of plant extracts using microbial test systems. Appl. Microbiol., 2009, vol. 106, pp. 1175–1183.
  29. Rios J.L., Recio M.C. Medicinal plants and antimicrobial activity. Ethnopharmacol., 2005, vol. 100, pp. 80–84.
  30. Sahu N.K., Balbhadra S.S., Choudhary J., Kohli D.V. Exploring pharmacological significance of chalcone scaffold: a review. Med. Chem., 2012, vol. 19, pp. 209–225.
  31. Saleem M., Nazir M., Ali M.S., Hussain H., Lee Y.S., Riaz N., Jabbar A. Antimicrobial natural products: an update on future antibiotic drug candidates. Prod. Rep., 2010, vol. 27, pp. 238–254.
  32. Schmieder R., Edwards R. Insights into antibiotic resistance through metagenomic approaches. Microbiol., 2012, vol. 7, pp. 73–89.
  33. Smirnova G.V., Samoylova Z.Y., Muzyka N.G., Oktyabrsky O.N. Influence of polyphenols on Escherichia coli resistance to oxidative stress. Free Radic. Biol. Med., 2009, vol. 46, pp. 759–768.
  34. Tamura M., Saito H., Kikuchi K., Ishigami T., Toyama Y., Takami M., Ochiai K. Antimicrobial activity of Gel-entrapped catechins toward oral microorganisms. Pharm. Bull., 2011, vol. 34, pp. 638–643.
  35. Valentova K., Stejskal P. Biosafety, antioxidant status, and metabolites in urine after consumption of dried cranberry juice in healthy women: a pilot double-blind placebo-controlled trial. Agric. Food Chem., 2007, vol. 55(8), pp. 3217–3224.
  36. Wang Q., Wang H., Xie M. Antibacterial mechanism of soybean isoflavone on Staphylococcus aureus. Microbiol., 2010, vol. 192, pp. 893–898.
  37. Williams C. Healthy eating: clarifying advice about fruit and vege-tables. BMJ, 1995, vol. 310, pp. 1453–1455.
  38. Wu D., Kong Y., Han C., Chen J., Hu L., Jiang H., Shen X. D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin. J. Antimicrob. Agents, 2008, vol. 32, pp. 421–426.
  39. Yang J., Li L., Jin H., Tan S., Qiu J., Yang L., Ding Y., Jiang Z. H., Jiang S., Liu S. Vaginal gel formulation based on theaflavin derivatives as a microbicide to prevent HIV sexual transmission. AIDS Res. Hum. Retroviruses, 2012, vol. 28, pp. 1498–1508.
  40. Zhang F., Luo S.Y., Ye Y.B., Zhao W.H., Sun X.G., Wang Z.Q., Li R., Sun Y.H., Tian W.X., Zhang Y.X. The antibacterial efficacy of an aceraceous plant [Shantung maple (Acer truncatum Bunge)] may be related to inhibition of bacterial beta-oxoacyl-acyl carrier protein reductase (FabG). Appl. Biochem., 2008, vol. 51, pp. 73–78.

Сведения об авторах

Солёнова Елена Александровна
ассистент кафедры фармакологии, клинической фармакологии и биохимии, Чувашский государственный университет, Россия, Чебоксары (elensoul@mail.ru; )
Николаевна Величковска Людмила Николаевна
кандидат медицинских наук, доцент кафедры факультетской и госпитальной терапии, Чувашский государственный университет, Россия, Чебоксары (lyuda_belchusova@mail.ru; )

Ссылка на статью

Солёнова Е.А., Николаевна Величковска Л.Н. Флавоноиды. Перспективы применения в антимикробной терапии [Электронный ресурс] // Acta medica Eurasica. – 2017. – №3. – С. 50-57. – URL: https://acta-medica-eurasica.ru/single/2017/3/7/.

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